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H2AFX 抗体 (Ser139)

This 兔 多克隆 anti-H2AFX antibody (Clone RB43837) specifically detects H2AFX in WB. The antibody is reactive with 人 samples.
产品编号 ABIN6243686
发货至: 中国
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Quick Overview for H2AFX 抗体 (Ser139) (ABIN6243686)

抗原

See all H2AFX 抗体
H2AFX (H2A Histone Family, Member X (H2AFX))

适用

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宿主

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克隆类型

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多克隆

标记

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This H2AFX antibody is un-conjugated

应用范围

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Western Blotting (WB)

克隆位点

RB43837
  • 抗原表位

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    AA 134-163, Ser139

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 134-163 amino acids from human.

    亚型

    IgG
  • 应用备注

    WB: 1:1000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    有效期

    6 months
  • 抗原

    H2AFX (H2A Histone Family, Member X (H2AFX))

    别名

    Histone H2A.X

    背景

    Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation.

    分子量

    15145

    UniProt

    P16104

    途径

    Telomere Maintenance, DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus
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