FZD10 抗体 (N-Term)
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北京 101111
Quick Overview for FZD10 抗体 (N-Term) (ABIN6243622)
抗原
See all FZD10 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 177-212, N-Term
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This FZD10 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 177-212 amino acids from the N-terminal region of human FZD10.
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亚型
- Ig Fraction
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应用备注
- WB: 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- FZD10 (Frizzled Family Receptor 10 (FZD10))
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别名
- FZD10
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背景
- Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
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分子量
- 65336
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UniProt
- Q9ULW2
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途径
- WNT signaling
抗原
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