CSF1R 抗体 (AA 910-940)
Quick Overview for CSF1R 抗体 (AA 910-940) (ABIN6243523)
抗原
See all CSF1R 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 910-940
-
纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
-
免疫原
- This mouse Csf1r antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 910-940 amino acids from mouse Csf1r.
-
亚型
- Ig Fraction
-
-
anti-Colony Stimulating Factor 1 Receptor (CSF1R) (AA 344-497) antibody
CSF1R 适用: 人 ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 6B9B9 unconjugated
anti-Colony Stimulating Factor 1 Receptor (CSF1R) (AA 344-497) antibodyCSF1R 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 6B9H2 unconjugated
anti-Colony Stimulating Factor 1 Receptor (CSF1R) (pTyr723) antibodyCSF1R 适用: 人, 犬 WB, ELISA, FACS, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Colony Stimulating Factor 1 Receptor (CSF1R) (AA 940-971) antibodyCSF1R 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Colony Stimulating Factor 1 Receptor (CSF1R) (Tyr809) antibodyCSF1R 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Colony Stimulating Factor 1 Receptor (CSF1R) (AA 21-120) antibodyCSF1R 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 3G12 unconjugated
anti-Colony Stimulating Factor 1 Receptor (CSF1R) (AA 20-152) antibodyCSF1R 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4C9G2 unconjugated
anti-Colony Stimulating Factor 1 Receptor (CSF1R) (AA 895-923), (C-Term) antibodyCSF1R 适用: 小鼠, 大鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB34462 unconjugated
anti-Colony Stimulating Factor 1 Receptor (CSF1R) (AA 895-923) antibodyCSF1R 适用: 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Colony Stimulating Factor 1 Receptor (CSF1R) (AA 201-300) antibodyCSF1R 适用: 人 ELISA, FACS, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- WB: 1:2000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
有效期
- 6 months
-
-
- CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))
-
别名
- Csf1r
-
背景
- Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP- 1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor.
-
分子量
- 109179
-
UniProt
- P09581
-
途径
- RTK signaling, Inositol Metabolic Process, Cell-Cell Junction Organization
抗原
-
