TRIP12 抗体 (AA 991-1023)
This anti-TRIP12 antibody is a 兔 多克隆 antibody detecting TRIP12 in WB. Suitable for 人.
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产品编号 ABIN6242961
发货至:
中国
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Quick Overview for TRIP12 抗体 (AA 991-1023) (ABIN6242961)
抗原
See all TRIP12 抗体
TRIP12
(Thyroid Hormone Receptor Interactor 12 (TRIP12))
适用
人
宿主
兔
克隆类型
多克隆
标记
This TRIP12 antibody is un-conjugated
应用范围
Western Blotting (WB)
克隆位点
RB54123
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抗原表位
- AA 991-1023
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预测反应
- B, Zf, M, Rat
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This TRIP12 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 991-1023 amino acids from the Central region of human TRIP12.
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亚型
- Ig Fraction
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anti-Thyroid Hormone Receptor Interactor 12 (TRIP12) (AA 1-240) antibody
TRIP12 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Hormone Receptor Interactor 12 (TRIP12) (AA 75-125) antibodyTRIP12 适用: 人, 犬, 豚鼠, Pig WB, IHC, IHC (p), IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- TRIP12 (Thyroid Hormone Receptor Interactor 12 (TRIP12))
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别名
- TRIP12
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背景
- E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.
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分子量
- 220434
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UniProt
- Q14669
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途径
- Nuclear Hormone Receptor Binding
抗原
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