PSME4 抗体 (AA 503-535)
The 兔 多克隆 anti-PSME4 antibody (Clone RB55279) (ABIN6242866) specifically detects PSME4 in WB.
The antibody is reactive with 人 samples.
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产品编号 ABIN6242866
发货至:
中国
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Quick Overview for PSME4 抗体 (AA 503-535) (ABIN6242866)
抗原
See all PSME4 抗体
PSME4
(Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))
适用
人
宿主
兔
克隆类型
多克隆
标记
This PSME4 antibody is un-conjugated
应用范围
Western Blotting (WB)
克隆位点
RB55279
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抗原表位
- AA 503-535
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预测反应
- B
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This PSME4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 503-535 amino acids from human PSME4.
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亚型
- Ig Fraction
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anti-Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4) (AA 1634-1843) antibody
PSME4 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4) (AA 105-198) antibodyPSME4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))
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别名
- PSME4
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背景
- Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.
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分子量
- 211334
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UniProt
- Q14997
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途径
- DNA Replication, Synthesis of DNA
抗原
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