KCTD11 抗体 (AA 21-53)
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- 抗原 See all KCTD11 抗体
- KCTD11 (Potassium Channel Tetramerisation Domain Containing 11 (KCTD11))
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抗原表位
- AA 21-53
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This KCTD11 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 预测反应
- M
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This KCTD11 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 21-53 amino acids from human KCTD11.
- 克隆位点
- RB54391
- 亚型
- Ig Fraction
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anti-Potassium Channel Tetramerisation Domain Containing 11 (KCTD11) (AA 41-90) antibody
KCTD11 适用: 人, 小鼠, 大鼠, Cow, 马, 兔, 豚鼠, Bat, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel Tetramerisation Domain Containing 11 (KCTD11) (AA 61-110) antibodyKCTD11 适用: 人, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel Tetramerisation Domain Containing 11 (KCTD11) (Internal Region) antibodyVerified KCTD11 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Potassium Channel Tetramerisation Domain Containing 11 (KCTD11) (N-Term) antibodyKCTD11 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:1000-1:2000. IHC-P: 1:25
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
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- 抗原
- KCTD11 (Potassium Channel Tetramerisation Domain Containing 11 (KCTD11))
- 别名
- KCTD11 (KCTD11 产品)
- 别名
- KCTD11 antibody, AF465352 antibody, Ren antibody, C17orf36 antibody, KCASH1 antibody, REN antibody, REN/KCTD11 antibody, potassium channel tetramerization domain containing 11 antibody, potassium channel tetramerisation domain containing 11 antibody, KCTD11 antibody, Kctd11 antibody
- 背景
- Plays a role as a marker and a regulator of neuronal differentiation, Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as an E3 ubiquitin-protein ligase towards HDAC1, leading to its proteasomal degradation. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock- down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.
- 分子量
- 25887
- UniProt
- Q693B1
- 途径
- Hedgehog Signaling
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