KCTD11 抗体 (AA 21-53)
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北京 101111
Quick Overview for KCTD11 抗体 (AA 21-53) (ABIN6242571)
抗原
See all KCTD11 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 21-53
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预测反应
- M
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This KCTD11 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 21-53 amino acids from human KCTD11.
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亚型
- Ig Fraction
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anti-Potassium Channel Tetramerisation Domain Containing 11 (KCTD11) (Internal Region) antibody
Verified KCTD11 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Potassium Channel Tetramerisation Domain Containing 11 (KCTD11) (AA 41-90) antibodyKCTD11 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, 兔, Bat, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel Tetramerisation Domain Containing 11 (KCTD11) (AA 61-110) antibodyKCTD11 适用: 人, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel Tetramerisation Domain Containing 11 (KCTD11) (N-Term) antibodyKCTD11 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Potassium Channel Tetramerisation Domain Containing 11 (KCTD11) (N-Term) antibodyKCTD11 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000-1:2000. IHC-P: 1:25
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- KCTD11 (Potassium Channel Tetramerisation Domain Containing 11 (KCTD11))
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别名
- KCTD11
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背景
- Plays a role as a marker and a regulator of neuronal differentiation, Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as an E3 ubiquitin-protein ligase towards HDAC1, leading to its proteasomal degradation. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock- down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.
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分子量
- 25887
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UniProt
- Q693B1
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途径
- Hedgehog Signaling
抗原
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