MUSK 抗体 (AA 600-860)
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Quick Overview for MUSK 抗体 (AA 600-860) (ABIN6242455)
抗原
See all MUSK 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 600-860
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纯化方法
- This antibody is purified through a protein G column, followed by dialysis against PBS.
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免疫原
- This mouse Musk antibody is generated from a mouse immunized with recombinant protein from mouse Musk.
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亚型
- IgG1 kappa
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anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 517-777) antibody
MUSK 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 35-65), (N-Term) antibodyMUSK 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB01497 unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 301-400) antibodyMUSK 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2H6 unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) antibodyMUSK 适用: 人, 小鼠 WB, FACS, IF 宿主: 兔 Polyclonal RB14743 unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 301-400) antibodyMUSK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F3 unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 24-209) antibodyMUSK 适用: 人 ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 10A4 unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) antibodyMUSK 适用: 小鼠, 大鼠 WB, IHC (p) 宿主: 小鼠 Monoclonal 6D1 unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) antibodyMUSK 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (N-Term) antibodyMUSK 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 829-859), (C-Term) antibodyMUSK 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB01500 unconjugated
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应用备注
- WB: 1:2000. IHC-P: 1:25
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))
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别名
- Musk
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背景
- Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation.
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分子量
- 96693
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UniProt
- Q61006
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途径
- RTK signaling, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development
抗原
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