MBD2 抗体 (AA 10-228)
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Quick Overview for MBD2 抗体 (AA 10-228) (ABIN6242434)
抗原
See all MBD2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 10-228
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纯化方法
- This antibody is purified through a protein G column, followed by dialysis against PBS.
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免疫原
- This MBD2 antibody is generated from a mouse immunized with a recombinant protein between 10-228 amino acids from human MBD2.
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亚型
- IgG1 kappa
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应用备注
- WB: 1:2000. IHC-P: 1:25
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))
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别名
- MBD2
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背景
- Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.
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分子量
- 43255
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UniProt
- Q9UBB5
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途径
- Chromatin Binding
抗原
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