E2F8 抗体 (AA 835-865)
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北京 101111
Quick Overview for E2F8 抗体 (AA 835-865) (ABIN6242297)
抗原
See all E2F8 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 835-865
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预测反应
- M, Rat
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This E2F8 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 835-865 amino acids from human E2F8.
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亚型
- Ig Fraction
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anti-E2F Transcription Factor 8 (E2F8) (Internal Region) antibody
Verified E2F8 适用: 人 ELISA, FACS, IF 宿主: 山羊 Polyclonal unconjugated
anti-E2F Transcription Factor 8 (E2F8) (C-Term) antibodyE2F8 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-E2F Transcription Factor 8 (E2F8) antibodyE2F8 适用: 人, 大鼠, 小鼠, Pig, 小鸡 FACS 宿主: 兔 Polyclonal unconjugated
anti-E2F Transcription Factor 8 (E2F8) (AA 1-240) antibodyE2F8 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-E2F Transcription Factor 8 (E2F8) (C-Term) antibodyE2F8 适用: 人 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-E2F Transcription Factor 8 (E2F8) (AA 1-431) antibodyE2F8 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3E9-2F5 unconjugated
anti-E2F Transcription Factor 8 (E2F8) (C-Term) antibodyE2F8 适用: 人, 大鼠, Pig, 犬, 豚鼠, 马, 猴, Bat, Hamster WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- E2F8 (E2F Transcription Factor 8 (E2F8))
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别名
- E2F8
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背景
- Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.
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分子量
- 94166
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UniProt
- A0AVK6
抗原
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