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- 抗原 See all E2F8 抗体
- E2F8 (E2F Transcription Factor 8 (E2F8))
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抗原表位
- C-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This E2F8 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 特异性
- E2F8 Antibody detects endogenous levels of total E2F8.
- 预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human E2F8, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
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anti-E2F Transcription Factor 8 (E2F8) (Internal Region) antibody
Verified E2F8 适用: 人 ELISA, FACS, IF 宿主: 山羊 Polyclonal unconjugated
anti-E2F Transcription Factor 8 (E2F8) antibodyE2F8 适用: 人, 小鼠, 大鼠, Pig, 小鸡 FACS 宿主: 兔 Polyclonal unconjugated
anti-E2F Transcription Factor 8 (E2F8) (AA 1-431) antibodyE2F8 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3E9-2F5 unconjugated
anti-E2F Transcription Factor 8 (E2F8) (C-Term) antibodyE2F8 适用: 人 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-E2F Transcription Factor 8 (E2F8) (AA 1-240) antibodyE2F8 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-E2F Transcription Factor 8 (E2F8) (AA 835-865) antibodyE2F8 适用: 人 WB 宿主: 兔 Polyclonal RB54144 unconjugated
anti-E2F Transcription Factor 8 (E2F8) (C-Term) antibodyE2F8 适用: 人, 大鼠, Pig, 犬, 豚鼠, 马, 猴, Bat, Hamster WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- E2F8 (E2F Transcription Factor 8 (E2F8))
- 别名
- E2F8 (E2F8 产品)
- 别名
- MGC130750 antibody, E2F8 antibody, E2F-8 antibody, RGD1308091 antibody, 4432406C08Rik antibody, AA410048 antibody, E2F transcription factor 8 antibody, E2F transcription factor 8 L homeolog antibody, E2F8 antibody, e2f8.L antibody, e2f8 antibody, E2f8 antibody
- 背景
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Description: Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.
Gene: E2F8
- 分子量
- 94kDa
- 基因ID
- 79733
- UniProt
- A0AVK6
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