p300 抗体 (Ser1834)
Quick Overview for p300 抗体 (Ser1834) (ABIN6242296)
抗原
See all p300 (EP300) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1807-1841, Ser1834
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1807-1841 amino acids from human.
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亚型
- Ig Fraction
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anti-E1A Binding Protein P300 (EP300) (AA 1-270) antibody
EP300 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-E1A Binding Protein P300 (EP300) (AA 731-830) antibodyEP300 适用: 人 WB, ELISA, IHC (p), IF 宿主: 小鼠 Monoclonal 1B1 unconjugated
anti-E1A Binding Protein P300 (EP300) (AA 2065-2414) antibodyEP300 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-E1A Binding Protein P300 (EP300) (AA 1351-1601) antibodyEP300 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-E1A Binding Protein P300 (EP300) (AA 1-158) antibodyEP300 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-E1A Binding Protein P300 (EP300) antibodyEP300 适用: 人 WB, IP, ICC, IF, ChIP, ChIP-seq 宿主: 小鼠 Monoclonal NM11 unconjugated
anti-E1A Binding Protein P300 (EP300) (AA 2124-2397) antibodyEP300 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-E1A Binding Protein P300 (EP300) (AA 731-831) antibodyEP300 适用: 人 WB, IHC, ELISA, IHC (p), IF 宿主: 小鼠 Monoclonal 1B1 unconjugated
anti-E1A Binding Protein P300 (EP300) (N-Term) antibodyEP300 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-E1A Binding Protein P300 (EP300) antibodyEP300 适用: 人 ELISA 宿主: 小鼠 Monoclonal 7D8A6 unconjugated
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应用备注
- WB: 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- p300 (EP300) (E1A Binding Protein P300 (EP300))
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别名
- EP300
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背景
- Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac). Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and enhances its transcriptional activity. Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity. Participates in CLOCK or NPAS2-regulated rhythmic gene transcription, exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter. Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:< a href="http://www.uniprot.org/citations/10733570" target="_blank">10733570, PubMed:< a href="http://www.uniprot.org/citations/11430825" target="_blank">11430825, PubMed:< a href="http://www.uniprot.org/citations/11701890" target="_blank">11701890, PubMed:< a href="http://www.uniprot.org/citations/12402037" target="_blank">12402037, PubMed:< a href="http://www.uniprot.org/citations/12586840" target="_blank">12586840, PubMed:< a href="http://www.uniprot.org/citations/12929931" target="_blank">12929931, PubMed:< a href="http://www.uniprot.org/citations/14645221" target="_blank">14645221, PubMed:< a href="http://www.uniprot.org/citations/15186775" target="_blank">15186775, PubMed:< a href="http://www.uniprot.org/citations/15890677" target="_blank">15890677, PubMed:< a href="http://www.uniprot.org/citations/16617102" target="_blank">16617102, PubMed:< a href="http://www.uniprot.org/citations/16762839" target="_blank">16762839, PubMed:< a href="http://www.uniprot.org/citations/18722353" target="_blank">18722353, PubMed:< a href="http://www.uniprot.org/citations/18995842" target="_blank">18995842, PubMed:< a href="http://www.uniprot.org/citations/23415232" target="_blank">23415232, PubMed:< a href="http://www.uniprot.org/citations/23911289" target="_blank">23911289, PubMed:< a href="http://www.uniprot.org/citations/23934153" target="_blank">23934153, PubMed:< a href="http://www.uniprot.org/citations/8945521" target="_blank">8945521). Acetylates XBP1 isoform 2, acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (By similarity).
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分子量
- 264161
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UniProt
- Q09472
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途径
- p53 Pathway, Notch Signaling, Interferon-gamma Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Regulation of Cell Size
抗原
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