SMC1A 抗体 (C-Term)
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Quick Overview for SMC1A 抗体 (C-Term) (ABIN6241986)
抗原
See all SMC1A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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免疫原
- Recombinant Protein
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应用备注
- WB: 1:1000. ICC: 1:100
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限制
- 仅限研究用
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状态
- Liquid
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储存条件
- 4 °C,-20 °C
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- SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))
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别名
- SMC1A
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背景
- Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.
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UniProt
- Q14683
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途径
- Stem Cell Maintenance
抗原
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