KAP1 抗体
Our Local Distributor
北京 101111
Quick Overview for KAP1 抗体 (ABIN6241957)
抗原
See all KAP1 (TRIM28) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
免疫原
- Recombinant Protein
-
-
anti-Tripartite Motif Containing 28 (TRIM28) (AA 576-835) antibody
TRIM28 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 28 (TRIM28) (C-Term) antibodyVerified TRIM28 适用: 人 IHC, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Tripartite Motif Containing 28 (TRIM28) (AA 379-524) antibodyTRIM28 适用: 人 WB, ELISA, IF, IHC (p), RNAi 宿主: 小鼠 Monoclonal 4E6 unconjugated
anti-Tripartite Motif Containing 28 (TRIM28) antibodyTRIM28 适用: 人 WB, IF, IP, ICC, IHC (p), ChIP 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 28 (TRIM28) (N-Term) antibodyTRIM28 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 28 (TRIM28) (AA 379-524) antibodyTRIM28 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1D11 unconjugated
anti-Tripartite Motif Containing 28 (TRIM28) (AA 22-291) antibodyTRIM28 适用: 人 WB, IHC, ELISA, IP 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 28 (TRIM28) antibodyTRIM28 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 28 (TRIM28) (pSer824) antibodyTRIM28 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 28 (TRIM28) (AA 1-835) antibodyTRIM28 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
-
-
应用备注
- IP: 1:500. WB: 1:1000. IHC: 1:100. ICC: 1:100
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
储存条件
- 4 °C,-20 °C
-
-
- KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))
-
别名
- KAP1 / TIF1 beta
-
背景
- Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation, the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors.
-
UniProt
- Q13263
-
途径
- Hedgehog Signaling, Positive Regulation of Response to DNA Damage Stimulus
抗原
-
