BNIP3 抗体
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Quick Overview for BNIP3 抗体 (ABIN6241195)
抗原
See all BNIP3 抗体适用
宿主
克隆类型
标记
应用范围
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免疫原
- A synthesized peptide
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应用备注
- WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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储存条件
- 4 °C,-20 °C
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- BNIP3 (BCL2/adenovirus E1B 19kDa Interacting Protein 3 (BNIP3))
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别名
- BNIP3
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背景
- Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.
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UniProt
- Q12983
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途径
- Autophagy, Brown Fat Cell Differentiation
抗原
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