MUC5AC 抗体 (CF®405S)
Quick Overview for MUC5AC 抗体 (CF®405S) (ABIN6186116)
抗原
See all MUC5AC 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
原理
- Mouse Monoclonal anti-Mucin 5AC (MUC5AC) (45M1), CF405S Conjugate
-
产品特性
- This MAb recognizes the peptide core of gastric mucin M1 (recently identified as Mucin 5AC). Its epitope is located in the C-terminal cysteine rich part of the peptide core of MUC5AC. TheA, epitope is destroyed by beta-mercaptoethanol but not by periodate treatment. This mucin is present in primary ovarian mucinous cancer but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2. Together with a panel of antibodies, Anti-MUC5AC may be useful for differential identification of primary mucinous ovarian tumors from colon adenocarcinoma metastatic to the ovary. MUC5AC antibodies may also be useful for identification of intestinal metaplasia as well as in the identification of pancreatic carcinoma and pre-cancerous changes vs. normal pancreas. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
-
免疫原
- M1 mucin preparation from the fluid of an ovarian mucinous cyst belonging to an O Le(a-b) patient
-
亚型
- IgG1 kappa
-
-
-
-
应用备注
-
Immunohistology formalin-fixed 1-2 μg/mL
- Does not react with cow, others not known
- Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes
- Immunofluorescence 1-2 μg/mL
- Flow Cytometry 0.5-1 μg/million cells in 0.1 mL
- Optimal dilution for a specific application should be determined by user
-
说明
-
Stomach
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 100 μg/mL
-
缓冲液
- PBS/0.1 % BSA/0.05 % azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Protect from light
-
-
- MUC5AC (Mucin 5AC, Oligomeric Mucus/gel-Forming (MUC5AC))
-
别名
- Mucin 5AC (MUC5AC)
-
背景
- Apomucin Major Airway Glycoprotein, Mucin 5 subtype AC tracheobronchial, Mucin 5 Subtypes A And C, Mucin 5AC oligomeric mucus/gel forming, Tracheobronchial Mucin (TBM)
-
分子量
- >1,000 kDa
-
基因ID
- 4586, 534332
-
UniProt
- P98088
抗原
-