MUC5AC 抗体
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北京 101111
Quick Overview for MUC5AC 抗体 (ABIN6940128)
抗原
See all MUC5AC 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- MUC5AC (Mucin 5AC / Gastric Mucin) Antibody
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特异性
- Mucins are a group of high molecular weight glycoproteins consisting of a mucin core protein and O-linked carbohydrates. Mucin 6 carries GlcNAc±1,Üí4Gal≤,ÜíR structures, indicating that ±1, 4-N-acetylglucosaminyltransferase is important to the formation of the mucous glycoproteins in vivo. Mucin 5AC is a gel-forming mucin that is secreted from surface mucous cells. Glucocorticoid is required for the expression of Mucin 5AC mRNA and high doses of hydrocortisone suppresses its expression. Additionally, asthmatic fluid stimulates Mucin 5AC synthesis several-fold. The pro-inflammatory cytokines IL-6 and TNF± stimulate Mucin 5AC secretion and thus contribute to the upregulation of mucin by chronic inflammation. Expression of Mucin 5AC is retinoic acid (RA)- or retinol-dependent, and RA control of mucin genes is mediated by the retinoid acid receptor RAR± and, to a lesser extent, by RAR≥. Thyroid hormone binding to thyroid receptors inhibits Mucin 5AC gene expression. Mucin 5AC is also expressed in normal endocervical epithelium, small intestine, gastric cells (Lewis type 1) and gastric metaplasia and it is one of the major mucins in the ethmoid mucosa.
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无交叉反应
- 牛
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纯化方法
- 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- M1 mucin preparation from the fluid of an ovarian mucinous cyst belonging to an O Le(a-b-) patient
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亚型
- IgG1, kappa
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anti-Mucin 5AC, Oligomeric Mucus/gel-Forming (MUC5AC) (AA 5528-5627) antibody
MUC5AC 适用: 人 IHC, FACS, ELISA 宿主: 小鼠 Monoclonal 8H8G6 unconjugated
anti-Mucin 5AC, Oligomeric Mucus/gel-Forming (MUC5AC) antibodyMUC5AC 适用: 人 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mucin 5AC, Oligomeric Mucus/gel-Forming (MUC5AC) (AA 28-327) antibodyMUC5AC 适用: 人 IHC, FACS, ELISA 宿主: 小鼠 Monoclonal 6C9D11 unconjugated
anti-Mucin 5AC, Oligomeric Mucus/gel-Forming (MUC5AC) (AA 5528-5627) antibodyMUC5AC 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 7E9D8 unconjugated
anti-Mucin 5AC, Oligomeric Mucus/gel-Forming (MUC5AC) (AA 4848-5030) antibodyMUC5AC 适用: 人, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Mucin 5AC, Oligomeric Mucus/gel-Forming (MUC5AC) (AA 601-700) antibodyMUC5AC 适用: 人, 小鼠, 大鼠 ELISA, ICC, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Mucin 5AC, Oligomeric Mucus/gel-Forming (MUC5AC) (AA 430-549) antibodyMUC5AC 适用: 小鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mucin 5AC, Oligomeric Mucus/gel-Forming (MUC5AC) (C-Term) antibodyMUC5AC 适用: 人 IHC, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Mucin 5AC, Oligomeric Mucus/gel-Forming (MUC5AC) antibodyMUC5AC 适用: 人 IHC 宿主: 小鼠 Monoclonal 109M unconjugated Recombinant Antibody
anti-Mucin 5AC, Oligomeric Mucus/gel-Forming (MUC5AC) (AA 351-450) antibodyMUC5AC 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2H7 unconjugated
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应用备注
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Positive Control: Human colon or stomach (IHC).
Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- MUC5AC (Mucin 5AC, Oligomeric Mucus/gel-Forming (MUC5AC))
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别名
- MUC5AC
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背景
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Apomucin Major Airway Glycoprotein, Mucin 5 subtype AC tracheobronchial, Mucin 5 Subtypes A And C, Mucin 5AC oligomeric mucus/gel forming, Tracheobronchial Mucin (TBM)
Human stomach.
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分子量
- 400-600 kDa
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基因ID
- 4586, 534332
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UniProt
- P98088
抗原
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