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Nkx2-2 抗体 (AA 1-119) (Biotin)

This Biotin-conjugated 小鼠 单克隆 anti-Nkx2-2 antibody (Clone NX2-1523) specifically detects Nkx2-2 in IHC, IF 和 FACS. The antibody is reactive with 人 samples.
产品编号 ABIN6181433
发货至: 中国
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Quick Overview for Nkx2-2 抗体 (AA 1-119) (Biotin) (ABIN6181433)

抗原

See all Nkx2-2 抗体
Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))

适用

  • 135
  • 54
  • 50
  • 24
  • 6
  • 6
  • 6
  • 5
  • 5
  • 4
  • 3
  • 2
  • 2
  • 2

宿主

  • 85
  • 57
小鼠

克隆类型

  • 92
  • 50
单克隆

标记

  • 58
  • 12
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 5
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
This Nkx2-2 antibody is conjugated to Biotin

应用范围

  • 78
  • 59
  • 47
  • 33
  • 28
  • 24
  • 13
  • 13
  • 12
  • 8
  • 7
  • 3
Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

克隆位点

NX2-1523
  • 抗原表位

    • 33
    • 8
    • 7
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-119

    原理

    Mouse Monoclonal anti-NKX2.2 (NX2/1523), Biotin Conjugate

    产品特性

    Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93 % and a specificity of 89 %, and aids in the differential diagnosis of small round cell tumors. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

    免疫原

    Human recombinant NKX2.2 protein fragment (aa1-119) (exact sequence is proprietary)

    亚型

    IgG1 kappa
  • 应用备注

    Immunohistology (formalin) 1-2 μg/mL
    • Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer,  pH 6.0, for 10-20 min followed by cooling at RT for 20 min
    • Flow Cytometry 0.5-1 μg/million cells/0.1 mL
    • Immunofluorescence 1-2 μg/mL
    • Optimal dilution for a specific application should be determined by user

    说明

    Pancreas or Ewing s sarcoma

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    100 μg/mL

    缓冲液

    PBS/0.1 % BSA/0.05 % azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • 抗原

    Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))

    别名

    NKX2.2

    背景

    Homeobox protein NK-2 homolog B, NK2 transcription factor like protein B, NK2 transcription factor related locus 2, NKX22, Nkx2b, tinman

    分子量

    40-50 kDa

    基因ID

    4821, 516922

    UniProt

    O95096

    途径

    Dopaminergic Neurogenesis
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