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BRCA1 抗体 (AA 445-620) (CF®640R)

Name: BRCA1 抗体 (AA 445-620) (CF®640R)
SKU: ABIN6175518
Availability: OutOfStock

This anti-BRCA1 antibody is a 小鼠单克隆 antibody detecting BRCA1 in ELISA, IF, FACS 和 Coat. Suitable for 人.

产品编号 ABIN6175518

发货至: 中国

Quick Overview for BRCA1 抗体 (AA 445-620) (CF®640R) (ABIN6175518)

抗原

See all BRCA1 抗体

BRCA1 (Breast Cancer 1 (BRCA1))

适用

人

宿主

小鼠

克隆类型

单克隆

标记

This BRCA1 antibody is conjugated to CF®640R

应用范围

ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Coating (Coat)

克隆位点

BRCA1-1472

Discover our top product BRCA1 Primary Antibody

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AA 445-620

原理

Mouse Monoclonal anti-BRCA1 (BRCA1/1472), CF640R Conjugate

产品特性

BRCA1 is a nuclear phosphoprotein that plays a role in maintaining genomic stability, and also acts as a tumor suppressor. It combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). It associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. It plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in BRCA1 are responsible for approximately 40 % of inherited breast cancers and more than 80 % of inherited breast and ovarian cancers. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

免疫原

Recombinant human BRCA1 protein fragment (aa445-620) (exact sequence is proprietary)

亚型

IgG1
anti-Breast Cancer 1 (BRCA1) (AA 19-83) antibody
BRCA1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) (pSer1423) antibody
BRCA1 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) (AA 229-335) antibody
BRCA1 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal 6C6D2 unconjugated

anti-Breast Cancer 1 (BRCA1) (AA 1661-1863) antibody
BRCA1 适用: 人, 大鼠, 小鼠 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) (Ser184), (Ser186) antibody
BRCA1 适用: 人, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) (AA 445-620) antibody
BRCA1 适用: 人 IHC, ISt, StM 宿主: 小鼠 Monoclonal BRCA1-1398 unconjugated

anti-Breast Cancer 1 (BRCA1) (AA 1314-1600), (AA 1314-1864) antibody
BRCA1 适用: 人 WB, IF, IP, FACS, ICC 宿主: 小鼠 Monoclonal RAY unconjugated

anti-Breast Cancer 1 (BRCA1) (AA 64-160) antibody
BRCA1 适用: 大鼠, 小鼠 ELISA, IHC (p), IF (p), FACS, IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) (pSer1524) antibody
BRCA1 适用: 人 ELISA, FACS 宿主: 兔 Polyclonal unconjugated

anti-Breast Cancer 1 (BRCA1) (AA 1524-1781) antibody
BRCA1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

应用备注
Immunofluorescence 1-2 μg/mL
- Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- ELISA For coating, order Ab without BSA
- Optimal dilution for a specific application should be determined by user
说明

A431 or HeLa Cells. Breast, Ovarian or Renal Cell Carcinoma

限制

仅限研究用
状态

Liquid

浓度

100 μg/mL

缓冲液

PBS/0.1 % BSA/0.05 % azide

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Protect from light
抗原

BRCA1 (Breast Cancer 1 (BRCA1))

别名

BRCA1

分子量

220 kDa

基因ID

672, 194143

UniProt

P38398

途径

Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus