Plakophilin 2 抗体 (Internal Region)
Our Local Distributor
北京 101111
Quick Overview for Plakophilin 2 抗体 (Internal Region) (ABIN615975)
抗原
See all Plakophilin 2 (PKP2) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 125-139, Internal Region
-
序列
- C-RGTAQYSSQK SVEER
-
特异性
- This antibody is expected to recognize both reported isoforms (NP_001005242.2, NP_004563.2).
-
交叉反应 (详细)
-
Species reactivity (expected):Human, Canine (Dog), Cow.
Species reactivity (tested):Mouse and Rat. -
纯化方法
- Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.
-
免疫原
- Peptide with sequence from the internal region of the protein sequence according to NP_001005242.2, NP_004563.2. Genename: PKP2
-
-
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
浓度
- 0.5 mg/mL
-
缓冲液
- Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
-
- Plakophilin 2 (PKP2)
-
别名
- Plakophilin-2
-
背景
- Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 1 mediates increases in desmosomal protein content, desmosome assembly and regulation of cell migration. Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Plakophilin 4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function.Synonyms: PKP2
-
基因ID
- 5318
-
NCBI登录号
- NP_004563
-
UniProt
- Q99959
-
途径
- Cell-Cell Junction Organization, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
抗原
-