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Septin 2 抗体 (AA 112-361)

This anti-Septin 2 antibody is a 兔 多克隆 antibody detecting Septin 2 in WB 和 IF. Suitable for 人.
产品编号 ABIN6147552
发货至: 中国

Quick Overview for Septin 2 抗体 (AA 112-361) (ABIN6147552)

抗原

See all Septin 2 (SEPT2) 抗体
Septin 2 (SEPT2)

适用

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宿主

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克隆类型

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多克隆

标记

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This Septin 2 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (IF)
  • 抗原表位

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    AA 112-361

    序列

    RDCFKTIISY IDEQFERYLH DESGLNRRHI IDNRVHCCFY FISPFGHGLK PLDVAFMKAI HNKVNIVPVI AKADTLTLKE RERLKKRILD EIEEHNIKIY HLPDAESDED EDFKEQTRLL KASIPFSVVG SNQLIEAKGK KVRGRLYPWG VVEVENPEHN DFLKLRTMLI THMQDLQEVT QDLHYENFRS ERLKRGGRKV ENEDMNKDQI LLEKEAELRR MQEMIARMQA QMQMQMQGGD GDGGALGHHV

    交叉反应

    人, 小鼠

    产品特性

    Polyclonal Antibodies

    纯化方法

    Affinity purification

    免疫原

    Recombinant fusion protein containing a sequence corresponding to amino acids 112-361 of human Septin 2 (NP_004395.1).

    亚型

    IgG
  • 应用备注

    WB,1:500 - 1:2000,IF,1:50 - 1:100

    说明

    HIGH QUALITY

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原

    Septin 2 (SEPT2)

    别名

    2-Sep

    背景

    Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.,SEPT2,DIFF6,NEDD-5,NEDD5,Pnutl3,hNedd5,septin-2,Cell Biology & Developmental Biology,Cell Cycle,Immunology & Inflammation,Cytokines,2-Sep

    分子量

    41 kDa/42 kDa/45 kDa

    基因ID

    4735

    UniProt

    Q15019
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