RFFL 抗体 (AA 1-190)
Quick Overview for RFFL 抗体 (AA 1-190) (ABIN6146886)
抗原
See all RFFL 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-190
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序列
- MWATCCNWFC LDGQPEEVPP PQGARMQAYS NPGYSSFPSP TGLEPSCKSC GAHFANTARK QTCLDCKKNF CMTCSSQVGN GPRLCLLCQR FRATAFQREE LMKMKVKDLR DYLSLHDIST EMCREKEELV LLVLGQQPVI SQEDRTRAST LSPDFPEQQA FLTQPHSSMV PPTSPNLPSS SAQATSVPPA
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human RFFL (NP_001017368.1).
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亚型
- IgG
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anti-Ring Finger and FYVE-Like Domain Containing 1 (RFFL) (AA 2-99) antibody
RFFL 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 3A4 unconjugated
anti-Ring Finger and FYVE-Like Domain Containing 1 (RFFL) (AA 1-190) antibodyRFFL 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger and FYVE-Like Domain Containing 1 (RFFL) (AA 265-294), (C-Term) antibodyRFFL 适用: 人 WB 宿主: 兔 Polyclonal RB40306 unconjugated
anti-Ring Finger and FYVE-Like Domain Containing 1 (RFFL) (AA 251-363) antibodyRFFL 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger and FYVE-Like Domain Containing 1 (RFFL) (AA 2-99) antibodyRFFL 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Ring Finger and FYVE-Like Domain Containing 1 (RFFL) (N-Term) antibodyRFFL 适用: 人, 小鼠, Cow, 马, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger and FYVE-Like Domain Containing 1 (RFFL) (AA 287-336) antibodyRFFL 适用: 人, 小鼠, 大鼠, 马, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger and FYVE-Like Domain Containing 1 (RFFL) (Middle Region) antibodyRFFL 适用: 人, 小鼠, 大鼠, Cow, 马, 犬, 兔, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB,1:500 - 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- RFFL (Ring Finger and FYVE-Like Domain Containing 1 (RFFL))
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别名
- RFFL
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背景
- E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling.,RFFL,CARP-2,CARP2,FRING,RIFIFYLIN,RNF189,RNF34L,Epigenetics & Nuclear Signaling,Cancer,Tumor suppressors,p53 pathway,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Caspases,Ubiquitin,RFFL
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分子量
- 36 kDa/39 kDa/40 kDa
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基因ID
- 117584
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UniProt
- Q8WZ73
抗原
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