PSMA 抗体 (AA 44-750) (PE)
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北京 101111
Quick Overview for PSMA 抗体 (AA 44-750) (PE) (ABIN614249)
抗原
See all PSMA (FOLH1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 44-750
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特异性
- This antibody recognizes extracellular domain of Glutamate Carboxypeptidase II (NAALADase, FOLH1, PSMA), an approximately 95-110 kDa transmembrane glycoprotein expressed mainly in tumour neovasculatures, nervous system and jejunum, which is an important prostate tumour marker.
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交叉反应 （详细）
- Species reactivity (tested):Human.
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亚型
- IgG1
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anti-Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1) (AA 44-750) antibody
FOLH1 适用: 人, 小鼠, 大鼠, Pig WB, IHC (p), ICC 宿主: 小鼠 Monoclonal GCP-04 unconjugated
anti-Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1) (AA 274-587) antibodyFOLH1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1) (AA 44-177) antibodyFOLH1 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 2D10E10 unconjugated
anti-Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1) (AA 275-588) antibodyFOLH1 适用: Pig WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1) (AA 232-433) antibodyFOLH1 适用: 人 WB, IHC, StM 宿主: 小鼠 Monoclonal FOLH1-2354 unconjugated
anti-Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1) (AA 44-750) antibodyFOLH1 适用: 人 FACS, IP, ICC, MS 宿主: 小鼠 Monoclonal GCP-05 unconjugated
anti-Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1) (AA 161-190) antibodyFOLH1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1) (AA 1-719) antibodyFOLH1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3B5 unconjugated
anti-Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1) antibodyFOLH1 适用: 人, 小鼠, 大鼠, 犬, 猴 WB, IF 宿主: 小鼠 Monoclonal 2E1 unconjugated
anti-Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1) (AA 117-351) antibodyFOLH1 适用: 人 WB, IHC (p), EIA 宿主: 小鼠 Monoclonal k1H7 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), 15 mM Sodium Azide, 0.2 % (w/v) high-grade protease free BSA
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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: "Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer." in: The EMBO journal, Vol. 25, Issue 6, pp. 1375-84, (2006) (PubMed).
: "Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 17, pp. 5981-6, (2005) (PubMed).
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: "Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer." in: The EMBO journal, Vol. 25, Issue 6, pp. 1375-84, (2006) (PubMed).
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- PSMA (FOLH1) (Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1))
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别名
- PSMA / FOLH1
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背景
- Glutamate carboxypeptidase II (GCPII), also known as N-acetyl-alpha-linked acidic dipeptidase I (NAALADase I), folate hydrolase (FOLH1), and prostate-specific membrane antigen (PSMA), is an approximately 95-110 kDa type II transmembrane glycoprotein expressed in various tissues. In nervous system GCPII cleaves abundant N-acetylaspartylglutamate, which is released from neurons in a calcium-dependent manner, to N-acetylaspartate and glutamate. As immoderate glutamate concentration is neurotoxic, GCPII contributes to pathological conditions regarding e.g. Alzheimer´s disease, Huntington´s disease, epilepsy, schizophrenia, stroke or neuropathic pain and appears to be an interesting therapeutic target. In jejunum GCPII hydrolyzes pteroylpoly-gamma-glutamate to folate and glutamate, enabling folate to be absorbed by gastrointestinal tract. GCPII, which is present in a number of tissues at low levels, is overexpressed in neovasculature of most solid tumours and is a target enzyme for diagnosis and treatment of prostate cancer. Normal human prostate express more mRNA coding for a cytosolic GCPII form truncated at the N-terminus (PSM´) than mRNA for membrane-bound GCPII, and this ratio is reversed upon malignant transformation.Synonyms: FOLH, Folate hydrolase 1, Folylpoly-gamma-glutamate carboxypeptidase, GCP2, Glutamate carboxypeptidase 2, Glutamate carboxypeptidase II, Membrane glutamate carboxypeptidase, N-acetylated-alpha-linked acidic dipeptidase I, NAALAD1, NAALAdase, PSM, Prostate-specific membrane antigen, Pteroylpoly-gamma-glutamate carboxypeptidase
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基因ID
- 2346
抗原
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