PSMA 抗体 (AA 44-750)
(3 references)-
- 抗原 See all PSMA (FOLH1) 抗体
- PSMA (FOLH1) (Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1))
-
抗原表位
- AA 44-750
-
适用
- 人
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This PSMA antibody is un-conjugated
-
应用范围
- Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunoprecipitation (IP), Cytometry by Time of Flight (CyTOF)
- 特异性
- The mouse monoclonal antibody GCP-05 recognizes extracellular domain (preferentially in native form) of glutamate carboxypeptidase II (NAALADase, FOLH1, PSMA), an approximately 95-110 kDa transmembrane glycoprotein expressed mainly in tumour neovasculatures, nervous system and jejunum, which is an important prostate tumour marker.
- 交叉反应 （详细）
- Human, Other not determined
- 纯化方法
- Purified by protein-A affinity chromatography.
- 纯度
- > 95 % (by SDS-PAGE)
- 免疫原
- amino acids 44-750 of human GCPII
- 克隆位点
- GCP-05
- 亚型
- IgG1
- Top Product
- Discover our top product FOLH1 Primary Antibody
-
anti-Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1) (AA 44-750) antibody
FOLH1 适用: 人, 小鼠, 大鼠, Pig WB, IHC (p), ICC 宿主: 小鼠 Monoclonal GCP-04 unconjugated
anti-Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1) antibodyFOLH1 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1) (AA 274-587) antibodyFOLH1 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1) (AA 44-177) antibodyFOLH1 适用: 人 WB, IHC, ELISA, FACS, ICC, Neut 宿主: 小鼠 Monoclonal 2D10E10 unconjugated
anti-Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1) (AA 275-588) antibodyFOLH1 适用: Pig WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1) (AA 232-433) antibodyFOLH1 适用: 人 WB, IHC, StM 宿主: 小鼠 Monoclonal FOLH1-2354 unconjugated
anti-Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1) (AA 161-190) antibodyFOLH1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1) (AA 1-719) antibodyFOLH1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3B5 unconjugated
anti-Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1) antibodyFOLH1 适用: 人, 小鼠, 大鼠, 犬, 猴 WB, IF 宿主: 小鼠 Monoclonal 2E1 unconjugated
anti-Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1) (AA 117-351) antibodyFOLH1 适用: 人 WB, IHC (p), EIA 宿主: 小鼠 Monoclonal k1H7 unconjugated
-
- 应用备注
- Flow cytometry: Recommended dilution: 1-4 μg/mL.
- 限制
- 仅限研究用
-
- 浓度
- 1 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Do not freeze.
- 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C. Do not freeze.
-
-
: "Comparative analysis of monoclonal antibodies against prostate-specific membrane antigen (PSMA)." in: The Prostate, Vol. 74, Issue 16, pp. 1674-90, (2014) (PubMed).
: "Expression of glutamate carboxypeptidase II in human brain." in: Neuroscience, Vol. 144, Issue 4, pp. 1361-72, (2007) (PubMed).
: "Identification of the N-glycosylation sites on glutamate carboxypeptidase II necessary for proteolytic activity." in: Protein science : a publication of the Protein Society, Vol. 13, Issue 6, pp. 1627-35, (2004) (PubMed).
-
: "Comparative analysis of monoclonal antibodies against prostate-specific membrane antigen (PSMA)." in: The Prostate, Vol. 74, Issue 16, pp. 1674-90, (2014) (PubMed).
-
- 抗原
- PSMA (FOLH1) (Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1))
- 别名
- GCPII / PSMA (FOLH1 产品)
- 别名
- FGCP antibody, FOLH antibody, GCP2 antibody, GCPII antibody, NAALAD1 antibody, NAALAdase antibody, PSM antibody, PSMA antibody, mGCP antibody, mopsm antibody, Naalad antibody, putative N-acetylated-alpha-linked acidic dipeptidase antibody, folate hydrolase 1B antibody, folate hydrolase 1 antibody, folate hydrolase (prostate-specific membrane antigen) 1 antibody, LOC451185 antibody, FOLH1B antibody, FOLH1 antibody, Folh1 antibody
- 背景
- Folate hydrolase 1,Glutamate carboxypeptidase II (GCPII), also known as N-acetyl-alpha-linked acidic dipeptidase I (NAALADase I), folate hydrolase (FOLH1), and prostate-specific membrane antigen (PSMA), is an approximately 95-110 kDa type II transmembrane glycoprotein expressed in various tissues. In nervous system GCPII cleaves abundant N-acetylaspartylglutamate, which is released from neurons in a calcium-dependent manner, to N-acetylaspartate and glutamate. As immoderate glutamate concentration is neurotoxic, GCPII contributes to pathological conditions regarding e.g. Alzheimer´s disease, Huntington´s disease, epilepsy, schizophrenia, stroke or neuropathic pain and appears to be an interesting therapeutic target. In jejunum GCPII hydrolyzes pteroylpoly-gamma-glutamate to folate and glutamate, enabling folate to be absorbed by gastrointestinal tract. GCPII, which is present in a number of tissues at low levels, is overexpressed in neovasculature of most solid tumours and is a target enzyme for diagnosis and treatment of prostate cancer. Normal human prostate express more mRNA coding for a cytosolic GCPII form truncated at the N-terminus (PSM´) than mRNA for membrane-bound GCPII, and this ratio is reversed upon malignant transformation.,GCP2, FOLH1, NAALADase I, PGGCP, FGGCP, FGCP,
- 基因ID
- 2346
- UniProt
- Q04609
-
