FZR1 抗体 (AA 224-493)
Quick Overview for FZR1 抗体 (AA 224-493) (ABIN6140852)
抗原
See all FZR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 224-493
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序列
- DLSVEGDSVT SVGWSERGNL VAVGTHKGFV QIWDAAAGKK LSMLEGHTAR VGALAWNAEQ LSSGSRDRMI LQRDIRTPPL QSERRLQGHR QEVCGLKWST DHQLLASGGN DNKLLVWNHS SLSPVQQYTE HLAAVKAIAW SPHQHGLLAS GGGTADRCIR FWNTLTGQPL QCIDTGSQVC NLAWSKHANE LVSTHGYSQN QILVWKYPSL TQVAKLTGHS YRVLYLAMSP DGEAIVTGAG DETLRFWNVF SKTRSTKESV SVLNLFTRIR
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交叉反应
- 人, 小鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 224-493 of human FZR1 (NP_057347.2).
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亚型
- IgG
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anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (AA 1-493) antibody
FZR1 适用: 人 WB, ELISA, IHC (p), PLA 宿主: 小鼠 Monoclonal 4C4 unconjugated
anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (N-Term) antibodyFZR1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (AA 141-240) antibodyFZR1 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (AA 1-494) antibodyFZR1 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 4C4 unconjugated
anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (AA 1-101) antibodyFZR1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3E12 unconjugated
anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (AA 1-493) antibodyFZR1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (AA 1-496) antibodyFZR1 适用: 人 WB 宿主: 小鼠 Monoclonal 1621CT637-76-67 unconjugated
anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (N-Term) antibodyFZR1 适用: 人, 小鼠, 大鼠, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (AA 35-84) antibodyFZR1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 斑马鱼, Pig, Bat, 猴, 小鸡, Hamster, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (N-Term) antibodyFZR1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB,1:500 - 1:2000,IF,1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))
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别名
- FZR1
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背景
- Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ over error-free, RBBP8-mediated homologous recombination (HR.,FZR1,CDC20C,CDH1,FZR,FZR2,HCDH,HCDH1,Cell Biology & Developmental Biology,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,FZR1
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分子量
- 44 kDa/54 kDa/55 kDa
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基因ID
- 51343
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UniProt
- Q9UM11
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途径
- DNA Replication, Synthesis of DNA
抗原
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