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CBP 抗体 (AA 100-200)

This anti-CBP antibody is a 兔 多克隆 antibody detecting CBP in WB, IHC 和 IF. Suitable for 人.
产品编号 ABIN6139021
发货至: 中国

Quick Overview for CBP 抗体 (AA 100-200) (ABIN6139021)

抗原

See all CBP (CREBBP) 抗体
CBP (CREBBP) (CREB Binding Protein (CREBBP))

适用

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宿主

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克隆类型

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多克隆

标记

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This CBP antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
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    AA 100-200

    序列

    GGQAQGQPNS ANMASLSAMG KSPLSQGDSS APSLPKQAAS TSGPTPAASQ ALNPQAQKQV GLATSSPATS QTGPGICMNA NFNQTHPGLL NSNSGHSLIN Q

    交叉反应

    人, 小鼠, 大鼠

    产品特性

    Polyclonal Antibodies

    纯化方法

    Affinity purification

    免疫原

    A synthetic peptide corresponding to a sequence within amino acids 100-200 of human CREBBP (NP_004371.2).

    亚型

    IgG
  • 应用备注

    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原

    CBP (CREBBP) (CREB Binding Protein (CREBBP))

    别名

    CREBBP

    背景

    This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms.,CREBBP,CBP,KAT3A,RSTS,RSTS1,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,Acetylation,Transcription Factors,Nuclear Receptor Signaling,Cancer,Signal Transduction,Cell Biology & Developmental Biology,TGF-b-Smad Signaling Pathway,Notch Signaling Pathway,Wnt/β-Catenin Signaling Pathway,Endocrine & Metabolism,Mitochondrial metabolism,Lipid Metabolism,Immunology & Inflammation,NF-kB Signaling Pathway,Neuroscience,Neurodegenerative Diseases,Stem Cells,Cardiovascular,Angiogenesis,Binding factor,Binding factor,CREBBP

    分子量

    260 kDa/265 kDa

    基因ID

    1387

    UniProt

    Q92793

    途径

    TCR Signaling, Interferon-gamma Pathway, Stem Cell Maintenance, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha
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