CTLA4 抗体
Quick Overview for CTLA4 抗体 (ABIN610400)
抗原
See all CTLA4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- CTLA-4 expressed on activated T cells.
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纯化方法
- Protein A purified
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免疫原
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Stimulated human PBL’,s and human CD152 Ig fusion protein.
Type of Immunogen: Fusion protein -
亚型
- IgG1 kappa
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应用备注
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Approved: ELISA, Flo, Func
Usage: Function: ANC152.2 blocks binding of CD152 (CTLA-4) Ig fusion protein to its CD80/CD86 receptor, and has been reported to modulate suppressive function of human T Regulatory Cells in Vitro. ANC152.2 can bind to intracellular CD152 in fixed permeabolized cells. The F(ab')2 form has been used to inhibit proliferation of activated T cells in vitro in a cholera toxin model. -
说明
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Target Species of Antibody: Human
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- 50 mM sodium phosphate, pH 7.5, 100 mM potassium chloride, 150 mM sodium chloride, 0.5 mg/mL Gentamicin sulfate
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储存液
- Gentamicin sulfate
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注意事项
- This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Do not freeze.
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储存条件
- 4 °C
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储存方法
- Store at 4°C. Do not freeze.
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: "c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis." in: The EMBO journal, Vol. 21, Issue 14, pp. 3704-14, (2002) (PubMed).
: "Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia." in: Oncogene, Vol. 21, Issue 44, pp. 6809-18, (2002) (PubMed).
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: "c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis." in: The EMBO journal, Vol. 21, Issue 14, pp. 3704-14, (2002) (PubMed).
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- CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
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别名
- CTLA4 / CD152
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背景
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Name/Gene ID: CTLA4
Synonyms: CTLA4, CD152, CELIAC3, CD152 antigen, CTLA-4, Celiac disease 3, IDDM12, GRD4, GSE, CD152 isoform -
基因ID
- 1493
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UniProt
- P16410
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途径
- Cancer Immune Checkpoints
抗原
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