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Contactin 1 抗体 (AA 100-150)

CNTN1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN571798
发货至: 中国
  • 抗原 See all Contactin 1 (CNTN1) 抗体
    Contactin 1 (CNTN1)
    抗原表位
    • 7
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 100-150
    适用
    • 35
    • 18
    • 16
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    宿主
    • 32
    • 2
    • 2
    • 1
    克隆类型
    • 36
    • 1
    多克隆
    标记
    • 21
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Contactin 1 antibody is un-conjugated
    应用范围
    • 24
    • 18
    • 8
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    原理
    Rabbit antibody to Contactin 1
    特异性
    Specific for contactin-1.
    交叉反应
    人, 大鼠
    交叉反应 (详细)
    Other species not yet tested.
    纯化方法
    IgG
    免疫原
    A synthetic peptide from AA 100-150 of human contactin 1 conjugated to an immunogenic carrier protein was used as the antigen.
    亚型
    IgG
    Top Product
    Discover our top product CNTN1 Primary Antibody
  • 应用备注
    IHC WB. A concentration of 10-50,micro,g,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.
    注意事项
    Avoid freeze and thaw cycles.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    有效期
    12 months
  • 抗原
    Contactin 1 (CNTN1)
    别名
    Contactin 1 (CNTN1 产品)
    背景
    FUNCTION: Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth. SUBUNIT: Monomer. Interacts with CNTNAP1 in cis form. Binds to the carbonic-anhydrase like domain of protein-tyrosine phosphatase zeta. Interacts with NOTCH1 and TNR. SUBCELLULAR LOCATION: Cell membrane, Lipid-anchor GPI-anchor. MISCELLANEOUS: F3 shares with L1 N-CAM MAG and other cell adhesion molecules from nervous tissue the L2/HNK-1 carbohydrate epitope. TISSUE SPECIFICITY: Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung pancreas kidney and skeletal muscle.
    UniProt
    Q12860
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