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ASIC3 抗体 (AA 50-100)

ACCN3 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN571604
发货至: 中国
  • 抗原 See all ASIC3 (ACCN3) 抗体
    ASIC3 (ACCN3) (Amiloride-Sensitive Cation Channel 3 (ACCN3))
    抗原表位
    • 9
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 50-100
    适用
    • 30
    • 10
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    大鼠
    宿主
    • 32
    • 3
    • 1
    克隆类型
    • 36
    多克隆
    标记
    • 21
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ASIC3 antibody is un-conjugated
    应用范围
    • 23
    • 18
    • 10
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    原理
    Rabbit antibody to extracellular ASIC3 (50-100)
    特异性
    Specific for ASIC3.
    交叉反应
    小鼠, 大鼠
    交叉反应 (详细)
    Other species not yet tested.
    纯化方法
    IgG
    免疫原
    A synthetic peptide from AA 50-100 of rat ASIC3 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse.
    亚型
    IgG
    Top Product
    Discover our top product ACCN3 Primary Antibody
  • 应用备注
    IHC WB. A concentration of 10-50,micro,g,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.
    注意事项
    Avoid freeze and thaw cycles.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    有效期
    12 months
  • 抗原
    ASIC3 (ACCN3) (Amiloride-Sensitive Cation Channel 3 (ACCN3))
    别名
    ASIC3 (ACCN3 产品)
    背景
    FUNCTION: Cation channel with high affinity for sodium which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. SUBUNIT: Homotetramer or heterotetramer with other ASIC proteins (Probable). Interacts with STOM and DLG4. Interacts with LIN7B MAGI1/BAIAP1 GOPC and ACCN1. SUBCELLULAR LOCATION: Cell membrane, Multi-pass membrane protein. Cytoplasm. Note: Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells. TISSUE SPECIFICITY: Expressed by sensory neurons. Strongly expressed in brain spinal chord lung lymph nodes kidney pituitary heart and testis. DEVELOPMENTAL STAGE: Expressed in fetal tissues expression increases in lung and kidney adult tissues.
    UniProt
    O35240
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