E2F1 抗体 (Internal Region, Lys120)
Quick Overview for E2F1 抗体 (Internal Region, Lys120) (ABIN571306)
抗原
See all E2F1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region, Lys120
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特异性
- Reacts with human E2F-1 acK120 and acK125
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交叉反应
- 小鼠
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交叉反应 (详细)
- May cross-react with E2F-1 from mouse and other species due to sequence homology
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纯化方法
- Antiserum
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免疫原
- Synthetic peptide derived from internal domain of human E2F-1 protein containing acetyl lysine 120 and 125
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亚型
- IgG
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应用备注
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Working dilution: Optimal dilutions should be determined by the end user.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Must be reconstituted in distilled water.
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储存条件
- 4 °C/-20 °C
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储存方法
- Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.
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有效期
- 24 months
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- E2F1 (E2F Transcription Factor 1 (E2F1))
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别名
- Transcription Factor E2F1 (E2F-1)
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背景
- Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis.
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UniProt
- Q01094
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途径
- p53 Pathway, Cell Division Cycle, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Autophagy
抗原
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