SOX10 抗体 (AA 115-269)
Quick Overview for SOX10 抗体 (AA 115-269) (ABIN5707895)
抗原
See all SOX10 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 115-269
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纯化方法
- Purified
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纯度
- Protein G affinity chromatography
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免疫原
- Amino acids 115-269 from the human protein were used as the immunogen for the recombinant SOX10 antibody.
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亚型
- IgG1 kappa
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anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (AA 115-269) antibody
SOX10 适用: 人, 小鼠 WB, IHC, StM 宿主: 小鼠 Monoclonal SOX10-991 unconjugated
anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (Middle Region) antibodySOX10 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 豚鼠, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (AA 147-252) antibodySOX10 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal 2E7E8 unconjugated
anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (AA 147-252) antibodySOX10 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 2E7B5 unconjugated
anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (AA 231-259) antibodySOX10 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB21835 unconjugated
anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (AA 115-269) antibodySOX10 适用: 人 WB, ELISA, Coat 宿主: 小鼠 Monoclonal SOX10-992 unconjugated
anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (AA 115-269) antibodySOX10 适用: 人, 小鼠 IHC, StM 宿主: 兔 Monoclonal SOX10-2311R unconjugated Recombinant Antibody
anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (AA 115-269) antibodySOX10 适用: 人, 小鼠 IHC, StM 宿主: 小鼠 Monoclonal rSOX10-1074 unconjugated Recombinant Antibody
anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (AA 200-300) antibodySOX10 适用: 人 WB, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-SRY (Sex Determining Region Y)-Box 10 (SOX10) (AA 231-259) antibodySOX10 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Optimal dilution of the recombinant SOX10 antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. WB: 0.5-1 μg/mL,Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1) -
限制
- 仅限研究用
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the recombinant SOX10 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))
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别名
- SOX10
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背景
- This mAb recognizes a protein of ~50 kDa identified as SOX10. This mAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX10 is moderately to strongly expressed in desmoplastic melanomas. SOX10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX10 expression is also observed in mast cells.
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途径
- Chromatin Binding
抗原
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