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SIRT1 抗体 (C-Term)

This anti-SIRT1 antibody is a 兔多克隆 antibody detecting SIRT1 in WB 和 ELISA. Suitable for 人.

Western Blot of Rabbit anti-SIRT1 antibody. (SIRT1 抗体 (C-Term))

1 image

产品编号 ABIN5706832

Supplier Product No.: 600-401-gw4

发货至: 中国

Quick Overview for SIRT1 抗体 (C-Term) (ABIN5706832)

抗原

See all SIRT1 抗体

SIRT1 (Sirtuin 1 (SIRT1))

适用

159
92
64
34
5
4
3
2
2
2
2
1
1

人

宿主

兔

克隆类型

多克隆

标记

84
15
11
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
1
1

This SIRT1 antibody is un-conjugated

应用范围

137
54
52
50
41
39
35
30
30
17
9
4
4
3
2
1
1
1

Western Blotting (WB), ELISA

Discover our top product SIRT1 Primary Antibody

抗原表位
32

16

16

12

9

6

6

6

5

4

3

3

3

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
C-Term

Supplier Product No.

600-401-gw4

Supplier

Rockland

原理

SIRT1 Antibody

交叉反应（详细）

Anti-SIRT1 is directed against human SIRT1.

产品特性

Synonyms: rabbit anti-SIRT1 antibody, NAD-dependent protein deacetylase sirtuin-1, hSIRT1, Regulatory protein SIR2 homolog 1, SIR2-like protein 1, hSIR2, SirtT1 75 kDa fragment, 75SirT1, SIRT-1, SIRT 1, SIR2L1

纯化方法

This product is an affinity purified antibody produced by immunoaffinity chromatography.

过滤

Sterile filtered

免疫原

Immunogen: Affinity purified Anti-SIRT1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide near the c-terminal of human SIRT1 protein.
Immunogen Type: Conjugated Peptide

亚型

IgG
anti-Sirtuin 1 (SIRT1) (AA 101-200) antibody
SIRT1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Sirtuin 1 (SIRT1) (AA 456-555) antibody
SIRT1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 7B7 unconjugated

anti-Sirtuin 1 (SIRT1) (AA 448-747) antibody
SIRT1 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated

anti-Sirtuin 1 (SIRT1) (AA 566-601), (C-Term) antibody
SIRT1 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB50965 unconjugated

anti-Sirtuin 1 (SIRT1) antibody
SIRT1 适用: 人 WB, IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 1F3 unconjugated

anti-Sirtuin 1 (SIRT1) antibody
KO Validated SIRT1 适用: 人 WB, IHC, IP, IF, ChIP 宿主: 兔 Polyclonal unconjugated

anti-Sirtuin 1 (SIRT1) (N-Term) antibody
SIRT1 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 豚鼠, 马, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated

anti-Sirtuin 1 (SIRT1) (AA 566-601) antibody
SIRT1 适用: 人, 小鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Sirtuin 1 (SIRT1) (AA 456-555) antibody
SIRT1 适用: 人 WB, IF, IHC (p), EIA 宿主: 小鼠 Monoclonal 7B7 unconjugated

anti-Sirtuin 1 (SIRT1) (pSer47) antibody
SIRT1 适用: 人, 小鼠, 大鼠, 犬 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

应用备注

Application Note: This affinity purified antibody has been tested for use in ELISA and western blot. Specific conditions for reactivity should be optimized by the end user. Expect a band ~62 or 81.7 kDa in size corresponding to SIRT1 by western blotting in the appropriate cell lysate or extract. Higher observed band ~125 kda is due to complexing proteins.
Western Blot Dilution: 1.0 μg/mL
ELISA Dilution: 5.0 μg/mL

限制

仅限研究用
状态

Liquid

浓度

1.00 mg/mL

缓冲液

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

有效期

12 months
抗原

SIRT1 (Sirtuin 1 (SIRT1))

别名

SIRT1

背景

Background: SIRT1 antibody detects human SIRT1 protein. SIRT1 is a member of the sirtuin family of protein-modifying enzymes. SIRT1 is a NAD+-dependent deacetylase that plays an important role in many cellular processes. SIRT1 protein is known to regulate epigenetic gene silencing and suppress recombination of rDNA. SIRT1 deacetylates a wide range of substrates, including p53, NF-kB, FOXO transcription factors, and PGC-1 alpha, with roles in cellular processes such as muscle differentiation, adipogenesis, protection from axonal degeneration, and life span extension. SIRT1 is downregulated in cells that have high insulin resistance and inducing its expression increases insulin sensitivity, suggesting the molecule is associated with improving insulin sensitivity. Furthermore, SIRT1 de-acetylates and affects the activity of both members of the PGC1-alpha/ERR-alpha complex, which are essential metabolic regulatory transcription factors. Anti-SIRT1 Antibody is significant for researchers involved in research areas including cancer, diabetes, aging, neurodegenerative, metabolic and cardiovascular diseases.

基因ID

23411

NCBI登录号

NP_001135970

UniProt

Q96EB6

途径

MAPK Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Carbohydrate Homeostasis, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Negative Regulation of intrinsic apoptotic Signaling

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