SSRP1 抗体
Quick Overview for SSRP1 抗体 (ABIN5699682)
抗原
See all SSRP1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- SSRP1 antibody
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免疫原
- structure specific recognition protein 1
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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HeLa cells were subjected to SDS PAGE followed by western blot with FNab08250(SSRP1 antibody) at dilution of 1:500
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限制
- 仅限研究用
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- SSRP1 (Structure Specific Recognition Protein 1 (SSRP1))
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别名
- SSRP1
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背景
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Synonyms: FACT complex subunit SSRP1|Chromatin-specific transcription elongation factor 80 kDa subunit|Facilitates chromatin transcription complex 80 kDa subunit (FACT 80 kDa subunit, FACTp80)|Facilitates chromatin transcription complex subunit SSRP1|Recombination signal sequence recognition protein 1|Structure-specific recognition protein 1 (hSSRP1)|T160|SSRP1|FACT80
Background: The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known.
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基因ID
- 6749
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UniProt
- Q08945
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途径
- Chromatin Binding
抗原
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