Patched 1 抗体 (C-Term)
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Quick Overview for Patched 1 抗体 (C-Term) (ABIN569656)
抗原
See all Patched 1 (PTCH1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- ELQDVECEER PR
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特异性
- This antibody is expected to recognise all reported isoforms of PTCH1. Variants (NP_001077073.1, NP_001077074.1, NP_001077075.1, NP_001077076.1) encode the same isoform.
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
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免疫原
- Peptide with sequence from the C Terminus of Human PTCH1
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anti-Patched 1 (PTCH1) (C-Term) antibody
Verified PTCH1 适用: 人, 小鼠 ELISA, IHC, IF 宿主: 山羊 Polyclonal unconjugated
anti-Patched 1 (PTCH1) antibodyPTCH1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Patched 1 (PTCH1) (AA 1214-1312) antibodyPTCH1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Patched 1 (PTCH1) (AA 213-422) antibodyPTCH1 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Patched 1 (PTCH1) (Internal Region) antibodyVerified PTCH1 适用: 人, 小鼠 WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Patched 1 (PTCH1) (N-Term) antibodyPTCH1 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Patched 1 (PTCH1) antibodyPTCH1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Patched 1 (PTCH1) (AA 770-970) antibodyPTCH1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Patched 1 (PTCH1) antibodyPTCH1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Patched 1 (PTCH1) (C-Term) antibodyPTCH1 适用: 人, 小鼠, 大鼠, 斑马鱼, 犬, Cow, 马, 豚鼠, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Patched 1 (PTCH1)
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别名
- PTCH1
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背景
- PTCH (Patched protein homolog 1) is a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). PTCH associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal.PTCH has a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. PTCH is expressed in the adult brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. It is also expressed in tumor cells but not in normal skin. During development PTCH is found in all major target tissues of sonic hedgehog, such as the ventral neural tube, somites, and tissues surrounding the zone of polarizing activity of the limb bud. Defects in PTCH are probably the cause of basal cell nevus syndrome also known as Gorlin syndrome or Gorlin-Goltz syndrome.Synonyms: PTC, PTC1, PTCH, Patched 1, Protein patched homolog 1
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基因ID
- 5727
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NCBI登录号
- NP_000255
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UniProt
- Q13635
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途径
- Hedgehog Signaling, Carbohydrate Homeostasis, Tube Formation
抗原
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