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MUC1 抗体 (AA 1062-1139)

Name: MUC1 抗体 (AA 1062-1139)
SKU: ABIN5693192
Availability: OutOfStock

MUC1 适用: 人, 小鼠, 大鼠 IHC, WB, ELISA 宿主: 兔 Polyclonal unconjugated

IHC analysis of MUC1 using anti-MUC1 antibody . (MUC1 抗体 (AA 1062-1139))

IHC

Western blot analysis of MUC1 using anti-MUC1 antibody . (MUC1 抗体 (AA 1062-1139))

IHC

5 images

(2 references)

产品编号 ABIN5693192

发货至: 中国

Datasheet as PDF

抗原 See all MUC1 抗体

MUC1 (Mucin 1 (MUC1))
抗原表位
21

16

16

14

7

5

5

5

4

4

3

3

3

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 1062-1139
适用
256

60

31

12

6

6

4

4

2

2

2

2

1
人, 小鼠, 大鼠
宿主
169

98

2

1

1
兔
Compatible Secondaries
克隆类型
146

117

8
多克隆
标记
158

20

13

7

7

6

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1
This MUC1 antibody is un-conjugated
应用范围
136

126

102

95

75

49

25

24

21

20

16

14

13

13

6

6

6

4

4

3

3

3

2

2

2

2

2

1

1

1

1

1
Immunohistochemistry (IHC), Western Blotting (WB), ELISA

品牌

Picoband™

交叉反应（详细）

No cross reactivity with other proteins.

产品特性

Rabbit IgG polyclonal antibody for MUC1 detection. Tested with WB, IHC-P, Direct ELISA in Human,Mouse,Rat.

免疫原

E. coli-derived human MUC1 recombinant protein (Position: S1062-V1139).

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anti-Mucin 1 (MUC1) (C-Term) antibody
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应用备注

Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
Application Details: Western blot, 0.1-0.5 μg/mL
Immunohistochemistry(Paraffin-embedded Section), 0.5-1 μg/mL
Direct ELISA, 0.1-0.5 μg/mL

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

缓冲液

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
Liu, Wei, Yang, Tan, Sun, Li, Che, Luan, Wang, Wang, Sun, Yin: "Globose, cystic olfactory ensheathing cell tumor: A case report and literature review." in: Oncology letters, Vol. 12, Issue 5, pp. 3981-3986, (2016) (PubMed).

Zhang, Chen, Shi, Xie, Liu, Zhang, Lai, Zuo, Chen, Liu, Wang: "Establishment of a new representative model of human ovarian cancer in mice." in: Journal of ovarian research, Vol. 6, Issue 1, pp. 9, (2013) (PubMed).
抗原

MUC1 (Mucin 1 (MUC1))

别名

MUC1 (MUC1 产品)

背景

Synonyms: Mucin-1, MUC-1, Breast carcinoma-associated antigen DF3, Cancer antigen 15-3, CA 15-3, Carcinoma-associated mucin, Episialin, H23AG, Krebs von den Lungen-6, KL-6, PEMT, Peanut-reactive urinary mucin, PUM, Polymorphic epithelial mucin, PEM, Tumor-associated epithelial membrane antigen, EMA, Tumor-associated mucin, CD227, Mucin-1 subunit alpha, MUC1-NT, MUC1-alpha, Mucin-1 subunit beta, MUC1-beta, MUC1-CT, MUC1, PUM
Tissue Specificity: Expressed on the apical surface of epithelial cells, especially of airway passages, breast and uterus. Also expressed in activated and unactivated T-cells. Overexpressed in epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Isoform Y is expressed in tumor cells only.
Background: Mucin 1, cell surface associated (MUC1) or polymorphic epithelial mucin (PEM) is a mucin encoded by the MUC1 gene in humans. This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. It is mapped to 1q22. Mucin 1 is a transmembrane mucin normally expressed on the apical borders of secretory epithelial cells. Overexpression of Mucin 1 is often associated with colon, breast, ovarian, lung and pancreatic cancers. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Mucin 1 stimulated ESR1-mediated transcription and contributed to estradiol-mediated growth and survival of breast cancer cells. This gene also can suppress pulmonary innate immunity, and its antiinflammatory activity may play an important modulatory role during microbial infection.

UniProt

P15941

途径

Negative Regulation of intrinsic apoptotic Signaling