Cytochrome C 抗体 (AA 2-105) (DyLight 488)
Quick Overview for Cytochrome C 抗体 (AA 2-105) (DyLight 488) (ABIN5693009)
抗原
See all Cytochrome C (CYCS) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 2-105
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原理
- Anti-Human Cytochrome C DyLight® 488 conjugated CYCS Antibody(monoclonal, 15F10)
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交叉反应 (详细)
- No cross-reactivity with other proteins.
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产品特性
- Anti-Human Cytochrome C DyLight® 488 conjugated CYCS Antibody (monoclonal, 15F10) -Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.
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免疫原
- E.coli-derived human Cytochrome C recombinant protein (Position: G2-E105). Human Cytochrome C shares 91% amino acid (aa) sequence identity with both mouse and rat Cytochrome C.
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亚型
- IgG1
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应用备注
- Flow Cytometry (Fixed), 1-3 μg/1x106 cells1. García-Heredia JM, et al. Specific nitration of tyrosines 46 and 48 makes cytochrome c assemble a non-functional apoptosome. FEBS Lett, 2012 Jan 20. 2. Rajagopal BS, et al. The hydrogen-peroxide-induced radical behaviour in human cytochrome c-phospholipid complexes: implications for the enhanced pro-apoptotic activity of the G41S mutant. Biochem J, 2013 Dec 15. 3. Simon M, et al. Versatility of non-native forms of human cytochrome c: pH and micellar concentration dependence. J Biol Inorg Chem, 2013 Jan.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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- Cytochrome C (CYCS) (Cytochrome C, Somatic (CYCS))
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别名
- CYCS
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背景
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Synonyms: Cytochrome c, CYCS, CYC
Background: CYCS is also known as CYC, HCS or THC4. This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.
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分子量
- 39 kDa
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基因ID
- 54205
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UniProt
- P99999
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途径
- Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
抗原
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