Functional Application: Agonist inducing BAFF, chemokines and integrins in vitro and in vivo.
限制
仅限研究用
状态
Liquid
浓度
1 mg/mL
缓冲液
Liquid. In PBS containing 10 % glycerol and 0.02 % sodium azide.
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C
储存方法
Stable for at least 1 year after receipt when stored at -20°C.
抗原
LTB
(Lymphotoxin beta (TNF Superfamily, Member 3) (LTB))
别名
LTbeta
背景
The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.