PAG1 抗体 (AA 412-424)
Quick Overview for PAG1 抗体 (AA 412-424) (ABIN5689872)
抗原
See all PAG1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 412-424
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特异性
- Recognizes mouse, rat and human PAG/Cbp.
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纯化方法
- Antigen affinity purified.
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免疫原
- Synthetic peptide corresponding to aa 412-424 of the N-terminal rat PAG including an additional N-terminal Cys residue.
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anti-phosphoprotein Associated with Glycosphingolipid Microdomains 1 (PAG1) (AA 97-432) antibody
PAG1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-phosphoprotein Associated with Glycosphingolipid Microdomains 1 (PAG1) (C-Term) antibodyPAG1 适用: 人, 小鼠, 大鼠, Cow WB, IP, IHC (p) 宿主: 小鼠 Monoclonal PAG-C1 unconjugated
anti-phosphoprotein Associated with Glycosphingolipid Microdomains 1 (PAG1) (AA 97-432) antibodyPAG1 适用: 人 WB, IHC (p), ICFC 宿主: 小鼠 Monoclonal MEM-255 unconjugated
anti-phosphoprotein Associated with Glycosphingolipid Microdomains 1 (PAG1) (AA 331-432) antibodyPAG1 适用: 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-phosphoprotein Associated with Glycosphingolipid Microdomains 1 (PAG1) (AA 97-432) antibodyPAG1 适用: 人, 小鼠 WB, IP, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-phosphoprotein Associated with Glycosphingolipid Microdomains 1 (PAG1) (AA 160-390) antibodyPAG1 适用: 小鼠 WB, IP, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-phosphoprotein Associated with Glycosphingolipid Microdomains 1 (PAG1) (AA 138-357) antibodyPAG1 适用: 大鼠 WB, IP, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-phosphoprotein Associated with Glycosphingolipid Microdomains 1 (PAG1) (AA 54-380) antibodyPAG1 适用: Cow WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-phosphoprotein Associated with Glycosphingolipid Microdomains 1 (PAG1) (AA 250-350) antibodyPAG1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Immunocytochemistry: (1:50). Immunoprecipitation: (5 μg/sample) . Western Blot: (1:1,000) . Optimal conditions must be determined individually for each application.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid. In PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for at least 1 year after receipt when stored at -20°C.
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- PAG1 (phosphoprotein Associated with Glycosphingolipid Microdomains 1 (PAG1))
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别名
- PAG/Cbp
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背景
- PAG [Cbp] is a ubiquitously expressed transmembrane adapter protein. Depending on its phosphorylation status, it appears as diffuse band(s) of 80-90 kDa by SDS-PAGE, with phosphorylation leading to a shift towards a higher apparent molecular mass. Tyrosine phosphorylated PAG recruits Csk to the membrane and negatively regulates Src family kinases via Csk-mediated phosphorylation. Upon T cell receptor engagement, PAG becomes dephosphorylated, thereby displacing Csk from the membrane and enabling the activation of the Src kinases Fyn and Lck. PAG negatively regulates TCR (T cell antigen receptor)-mediated signaling in T cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. It promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. It inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins and may be involved in cell adhesion signaling.
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基因ID
- 64019
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UniProt
- Q9JM80
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途径
- p53 Pathway, TCR Signaling, EGFR Signaling Pathway, CXCR4-mediated Signaling Events
抗原
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