SYK 抗体 (AA 321-325)
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Quick Overview for SYK 抗体 (AA 321-325) (ABIN5689584)
抗原
See all SYK 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 321-325
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特异性
- This antibody detects endogenous level of total syk protein.
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纯化方法
- Antibodies were purified by affinity-chromatography using epitope-specific peptide.
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免疫原
- syk (Ab-323) antibody was raised against a peptide sequence around aa. 321~325 (N-P-Y-E-P) derived from Human syk.
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应用备注
- Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store antibody at -20°C for up to one year.
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- SYK (Spleen tyrosine Kinase (SYK))
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别名
- syk
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背景
- Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C γ,dependent pathway, when phosphorylated on Tyr-348 and Tyr-352. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion
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分子量
- 72 kDa
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基因ID
- 6850
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NCBI登录号
- NP_001128524
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UniProt
- P43405
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途径
- Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Thromboxane A2 Receptor Signaling, BCR Signaling
抗原
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