PKC theta 抗体 (AA 674-678)
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Quick Overview for PKC theta 抗体 (AA 674-678) (ABIN5689324)
抗原
See all PKC theta (PRKCQ) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 674-678
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特异性
- This antibody detects endogenous level of total PKCΘ, protein.
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纯化方法
- Antibodies were purified by affinity-chromatography using epitope-specific peptide.
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免疫原
- PKCtheta (Ab-676) antibody was raised against a peptide sequence around aa. 674~678 (R-L-S-F-A) derived from Human PKCΘ,.
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应用备注
- Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store antibody at -20°C for up to one year.
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- PKC theta (PRKCQ) (Protein Kinase C, theta (PRKCQ))
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别名
- PKCtheta
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背景
- This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-κ,-B in mature T lymphocytes. Required for interleukin-2 (IL2) production. PKC is activated by diacylglycerol. which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
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分子量
- 80 kDa
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基因ID
- 5588
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NCBI登录号
- NP_006248
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UniProt
- Q04759
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途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Thromboxane A2 Receptor Signaling
抗原
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