PKC theta 抗体 (pThr538)
(1 reference)-
- 抗原 See all PKC theta (PRKCQ) 抗体
- PKC theta (PRKCQ) (Protein Kinase C, theta (PRKCQ))
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抗原表位
- pThr538
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PKC theta antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 交叉反应
- 人, 小鼠
- 预测反应
- Rat,Dog
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic phosphopeptide derived from human PRKCQ around the phosphorylation site of Thr538
- 亚型
- IgG
- Top Product
- Discover our top product PRKCQ Primary Antibody
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anti-Protein Kinase C, theta (PRKCQ) (pSer676) antibody
PRKCQ 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, theta (PRKCQ) (pSer676) antibodyPRKCQ 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, theta (PRKCQ) (AA 380-634) antibodyPRKCQ 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, theta (PRKCQ) (C-Term) antibodyPRKCQ 适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, theta (PRKCQ) (pSer676) antibodyPRKCQ 适用: 人, 小鼠, 兔 WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, theta (PRKCQ) (AA 15-294) antibodyPRKCQ 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, theta (PRKCQ) (pSer676) antibodyPRKCQ 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, theta (PRKCQ) (pSer695) antibodyPRKCQ 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, theta (PRKCQ) (C-Term) antibodyPRKCQ 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, theta (PRKCQ) (N-Term) antibodyPRKCQ 适用: 小鼠 WB, ELISA 宿主: 小鼠 Monoclonal M217 unconjugated
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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: "Evidence of microglial activation following exposure to serum from first-onset drug-naïve schizophrenia patients." in: Brain, behavior, and immunity, Vol. 67, pp. 364-373, (2018) (PubMed).
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: "Evidence of microglial activation following exposure to serum from first-onset drug-naïve schizophrenia patients." in: Brain, behavior, and immunity, Vol. 67, pp. 364-373, (2018) (PubMed).
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- 抗原
- PKC theta (PRKCQ) (Protein Kinase C, theta (PRKCQ))
- 别名
- PRKCQ (PRKCQ 产品)
- 别名
- PRKCT antibody, nPKC-theta antibody, A130035A12Rik antibody, AW494342 antibody, PKC-0 antibody, PKC-theta antibody, PKCtheta antibody, Pkcq antibody, protein kinase C theta antibody, protein kinase C eta antibody, protein kinase C, theta antibody, PRKCQ antibody, PRKCH antibody, Prkcq antibody
- 背景
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Synonyms: PRKCT, nPKC-theta, Protein kinase C theta type, PRKCQ
Background: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates to the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response.
- 基因ID
- 5588
- UniProt
- Q04759
- 途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Thromboxane A2 Receptor Signaling
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