E2F1 抗体 (AA 430-434)
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北京 101111
Quick Overview for E2F1 抗体 (AA 430-434) (ABIN5689264)
抗原
See all E2F1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 430-434
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特异性
- This antibody detects endogenous levels of total E2F-1 protein.
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纯化方法
- Antibodies were purified by affinity-chromatography using epitope-specific peptide.
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免疫原
- E2F-1 antibody was raised against a peptide sequence around aa.430~434 (G-D-L-T-P) derived from Human E2F-1.
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应用备注
- Western Blot: 1:500~1:1000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store antibody at -20°C for up to one year.
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- E2F1 (E2F Transcription Factor 1 (E2F1))
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别名
- E2F 1
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背景
- Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis.
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分子量
- 70 kDa
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基因ID
- 1869
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NCBI登录号
- NP_005216
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UniProt
- Q01094
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途径
- p53 Pathway, Cell Division Cycle, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Autophagy
抗原
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