The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with mouse, human, chicken, bovine, canine, non-human primate, Xenopus, and Zebrafish tissues based on the fact that these species have 100 % homology with the amino acid sequence used as antigen.
限制
仅限研究用
状态
Liquid
缓冲液
100 μLin 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.
储存条件
-20 °C
储存方法
MEK5 antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
抗原
MAP2K5
(Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))
别名
MEK5
背景
MEK5 (also known as MKK5) is a dual specificity serine/threonine protein kinase belonging to the MAP kinase kinase family. MEK5 has been shown to specifically activate ERK5 (Zhou et al., 1995) whereas MEK5 itself is regulated by MEKK3 (Chao et al., 1999). An important link between MEK5 and metastatic prostrate cancer has been demonstrated (Mehta et.al., 2003). Dual phosphorylation of Ser311 and Thr315 have been implicated in cell proliferation (Cameron et al., 2004).