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CD40 抗体 (AA 21-193)

This anti-CD40 antibody is a 小鼠 单克隆 antibody detecting CD40 in FACS 和 ELISA. Suitable for 人.
产品编号 ABIN5684134
发货至: 中国

Quick Overview for CD40 抗体 (AA 21-193) (ABIN5684134)

抗原

See all CD40 抗体
CD40

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This CD40 antibody is un-conjugated

应用范围

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Flow Cytometry (FACS), ELISA

克隆位点

4C3B8
  • 抗原表位

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    AA 21-193

    原理

    CD40 Antibody

    纯化方法

    Purified antibody

    免疫原

    Purified recombinant fragment of human CD40 (AA: 21-193) expressed in E. Coli.

    亚型

    IgG1
  • 应用备注

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified antibody in PBS with 0.05 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • 抗原

    CD40

    别名

    CD40

    背景

    This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

    分子量

    30.6 kDa

    基因ID

    958

    UniProt

    P25942

    途径

    NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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