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CERS6 抗体 (AA 62-131)

Name: CERS6 抗体 (AA 62-131)
SKU: ABIN566978
Availability: OutOfStock

There are 9+ publications for this product available. The 小鼠多克隆 anti-CERS6 antibody is suitable to detect CERS6 in samples from 人. It has been validated for WB 和 ELISA.

Western Blot detection against Immunogen (33. (CERS6 抗体 (AA 62-131))

LASS6 polyclonal antibody (A01), Lot # 061229JCSa Western Blot analysis of LASS6 expression in IMR-32 (CERS6 抗体 (AA 62-131))

2 images

(9 references)

产品编号 ABIN566978

发货至: 中国

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Quick Overview for CERS6 抗体 (AA 62-131) (ABIN566978)

抗原

See all CERS6 抗体

CERS6 (Ceramide Synthase 6 (CERS6))

适用

人

宿主

小鼠

克隆类型

多克隆

标记

This CERS6 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA

Discover our top product CERS6 Primary Antibody

抗原表位
8

7

5

5

2

1
AA 62-131

原理

Mouse polyclonal antibody raised against a partial recombinant LASS6.

序列

PCAIALNIQA NGPQIAPPNA ILEKVFTAIT KHPDEKRLEG LSKQLDWDVR SIQRWFRQRR NQEKPSTLTR

交叉反应

人

产品特性

Antibody Reactive Against Recombinant Protein.

免疫原

LASS6 (NP_982288, 62 a.a. ~ 131 a.a) partial recombinant protein with GST tag.
anti-Ceramide Synthase 6 (CERS6) (AA 62-131) antibody
CERS6 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 5H7 unconjugated

anti-Ceramide Synthase 6 (CERS6) (AA 62-131) antibody
CERS6 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6B8 unconjugated

anti-Ceramide Synthase 6 (CERS6) (AA 324-392) antibody
CERS6 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Ceramide Synthase 6 (CERS6) (N-Term) antibody
CERS6 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, Hamster, 兔 WB 宿主: 兔 Polyclonal unconjugated

anti-Ceramide Synthase 6 (CERS6) (N-Term) antibody
CERS6 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated

anti-Ceramide Synthase 6 (CERS6) (N-Term) antibody
CERS6 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, 犬, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated

anti-Ceramide Synthase 6 (CERS6) (N-Term) antibody
CERS6 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Ceramide Synthase 6 (CERS6) (N-Term) antibody
CERS6 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Ceramide Synthase 6 (CERS6) (N-Term) antibody
CERS6 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated

anti-Ceramide Synthase 6 (CERS6) (AA 324-392) antibody (HRP)
CERS6 适用: 人 ELISA 宿主: 兔 Polyclonal HRP

应用备注

Optimal working dilution should be determined by the investigator.

限制

仅限研究用
状态

Liquid

缓冲液

50 % glycerol

注意事项

Aliquot to avoid repeated freezing and thawing.

储存条件

-20 °C

储存方法

Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Schüll, Günther, Brodesser, Seeger, Tosetti, Wiegmann, Pongratz, Diaz, Witt, Andree, Brinkmann, Krönke, Wiesner, Kashkar: "Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6." in: Cell death & disease, Vol. 6, pp. e1691, (2015) (PubMed).

Cheng, Bai, Beckham, Marrison, Yount, Young, Lu, Bartlett, Wu, Keane, Armeson, Marshall, Keane, Smith, Jones, Drake, Bielawska, Norris, Liu: "Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse." in: The Journal of clinical investigation, Vol. 123, Issue 10, pp. 4344-58, (2013) (PubMed).

Separovic, Breen, Joseph, Bielawski, Pierce, VAN Buren, Gudz: "Ceramide synthase 6 knockdown suppresses apoptosis after photodynamic therapy in human head and neck squamous carcinoma cells." in: Anticancer research, Vol. 32, Issue 3, pp. 753-60, (2012) (PubMed).

Separovic, Breen, Joseph, Bielawski, Pierce, VAN Buren, Gudz: "siRNA-mediated down-regulation of ceramide synthase 1 leads to apoptotic resistance in human head and neck squamous carcinoma cells after photodynamic therapy." in: Anticancer research, Vol. 32, Issue 7, pp. 2479-85, (2012) (PubMed).

Senkal, Ponnusamy, Manevich, Meyers-Needham, Saddoughi, Mukhopadyay, Dent, Bielawski, Ogretmen et al.: "Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi ..." in: The Journal of biological chemistry, Vol. 286, Issue 49, pp. 42446-58, (2011) (PubMed).

Senkal, Ponnusamy, Bielawski, Hannun, Ogretmen: "Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 24, Issue 1, pp. 296-308, (2010) (PubMed).

White-Gilbertson, Mullen, Senkal, Lu, Ogretmen, Obeid, Voelkel-Johnson: "Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells." in: Oncogene, Vol. 28, Issue 8, pp. 1132-41, (2009) (PubMed).

Senkal, Ponnusamy, Rossi, Bialewski, Sinha, Jiang, Jazwinski, Hannun, Ogretmen: "Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas." in: Molecular cancer therapeutics, Vol. 6, Issue 2, pp. 712-22, (2007) (PubMed).

Yu, Novgorodov, Chudakova, Zhu, Bielawska, Bielawski, Obeid, Kindy, Gudz: "JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunction." in: The Journal of biological chemistry, Vol. 282, Issue 35, pp. 25940-9, (2007) (PubMed).
抗原

CERS6 (Ceramide Synthase 6 (CERS6))

别名

LASS6

背景

Full Gene Name: LAG1 homolog, ceramide synthase 6
Synonyms: CerS6,MGC129949,MGC129950

基因ID

253782

NCBI登录号

NM_203463