Calpastatin 抗体 (AA 275-310)
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Quick Overview for Calpastatin 抗体 (AA 275-310) (ABIN5647087)
抗原
See all Calpastatin (CAST) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 275-310
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纯化方法
- Antigen affinity purified
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免疫原
- Amino acids 275-310 (QEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLR-human) were used as the immunogen for the Calpastatin antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the Calpastatin antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL,FACS: 1-3 μg/10^6 cells,Immunohistochemistry (FFPE): 1-2 μg/mL
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限制
- 仅限研究用
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- -20 °C
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储存方法
- After reconstitution, the Calpastatin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- Calpastatin (CAST)
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别名
- Calpastatin
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背景
- Calpastatin is a protein that in humans is encoded by the CAST gene. It is mapped to 5q15. The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described.
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UniProt
- P20810
抗原
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