Axin 抗体 (AA 546-752)
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- 抗原 See all Axin (AXIN1) 抗体
- Axin (AXIN1) (Axin 1 (AXIN1))
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抗原表位
- AA 546-752
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Axin antibody is un-conjugated
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应用范围
- ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)
- 原理
- AXIN1 Antibody
- 纯化方法
- Purified antibody
- 免疫原
- Purified recombinant fragment of human AXIN1 (AA: 546-752) expressed in E. Coli.
- 克隆位点
- 4E9F1
- 亚型
- IgG2b
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- 应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/50 - 1/250
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- 抗原
- Axin (AXIN1) (Axin 1 (AXIN1))
- 别名
- AXIN1 (AXIN1 产品)
- 背景
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This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants.
- 分子量
- 95.6 kDa
- 基因ID
- 8312
- UniProt
- O15169
- 途径
- WNT signaling, Sensory Perception of Sound, Regulation of G-Protein Coupled Receptor Protein Signaling
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