BTRC 抗体 (AA 24-151)
Quick Overview for BTRC 抗体 (AA 24-151) (ABIN5611131)
抗原
See all BTRC 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 24-151
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原理
- BTRC Antibody
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纯化方法
- Purified antibody
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免疫原
- Purified recombinant fragment of human BTRC (AA: 24-151) expressed in E. Coli.
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亚型
- IgG1
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应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- BTRC (beta-Transducin Repeat Containing (BTRC))
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别名
- BTRC
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背景
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This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class, in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6.
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分子量
- 68.9 kDa
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基因ID
- 8945
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UniProt
- Q9Y297
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途径
- Cell Division Cycle, Hedgehog Signaling
抗原
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