Caspase 2 抗体 (Subunit p19)
Quick Overview for Caspase 2 抗体 (Subunit p19) (ABIN5564278)
抗原
See all Caspase 2 (CASP2) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- Subunit p19
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特异性
- Recognizes an epitope in the p19 subunit of human, mouse, rat, monkey and dog caspase-2. Detects bands of ~51 kDa (procaspase-2), ~32 kDa and ~18 kDa (cleavage products) by Western blot.
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交叉反应
- 犬, 人, 猴, 小鼠, 大鼠
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纯度
- >95 % (SDS-PAGE)
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内毒素水平
- <0.1EU/μg purified protein (LAL test, Lonza).
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免疫原
- Recombinant human caspase-2 (p19 subunit).
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亚型
- IgG2a
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anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (AA 334-452) antibody
CASP2 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (AA 153-452) antibodyCASP2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (AA 198-226) antibodyCASP2 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) antibodyCASP2 适用: 人 WB, ELISA, IHC 宿主: 兔 Monoclonal 3D4 unconjugated Recombinant Antibody
anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (AA 417-439), (C-Term) antibodyCASP2 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (Cleaved-Gly170) antibodyCASP2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (AA 2-452) antibodyCASP2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (Internal Region) antibodyCASP2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (AA 121-220) antibodyCASP2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1C11 unconjugated
anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (AA 121-220) antibodyCASP2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- In PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. -
有效期
- 12 months
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- Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))
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别名
- Caspase-2
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背景
- Caspase-2 is a Class I caspase with a long prodomain necessary for nuclear localization. Upon activation of the apoptotic pathway, the procaspase is cleaved into smaller fragments. Caspase-2 is the nuclear apoptotic respondent to cellular genotoxic stress or mitotic catastrophe and is involved in the activation cascade of caspases responsible for apoptosis execution. Activation occurs upon recruitment to a complex containing a p53-induced death domain protein, PIDD. This suggests caspase-2 can be a nuclear initiator caspase with a requirement for caspase-9 and caspase-3 activation in downstream apoptotic events. In apoptotic pathways resulting from UV-induced DNA damage, processing of caspase-2 occurs downstream of mitochondrial dysfunction and of caspase-9 and caspase-3 activation, extending a possible role for caspase-2 as a parallel effector caspase.
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UniProt
- P42575
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途径
- Apoptosis, Caspase Cascade in Apoptosis, Neurotrophin Signaling Pathway
抗原
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