(27 references)-
- 抗原 See all Caspase 2 (CASP2) 抗体
- Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))
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抗原表位
- AA 417-439, C-Term
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适用
- 人, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Caspase 2 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 原理
- Rabbit IgG polyclonal antibody for Caspase-2(CASP2) detection. Tested with WB in Human,Mouse,Rat.
- 序列
- REGYAPGTEF HRCKEMSEYC STL
- 交叉反应 （详细）
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Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities. - 产品特性
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Rabbit IgG polyclonal antibody for Caspase-2(CASP2) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: caspase 2, apoptosis-related cysteine peptidase
Protein Name: Caspase-2(CASP-2) - 纯化方法
- Immunogen affinity purified.
- 免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human Caspase-2(417-439aa REGYAPGTEFHRCKEMSEYCSTL), identical to the related rat and mouse sequences.
- 亚型
- IgG
- Top Product
- Discover our top product CASP2 Primary Antibody
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anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (AA 334-452) antibody
CASP2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) antibodyCASP2 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (AA 153-452) antibodyCASP2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (AA 198-226) antibodyCASP2 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) antibodyCASP2 适用: 人 WB, ELISA, IHC 宿主: 兔 Monoclonal 3D4 unconjugated Recombinant Antibody
anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (Cleaved-Gly170) antibodyCASP2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (AA 2-452) antibodyCASP2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (AA 121-220) antibodyCASP2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (Ser197) antibodyCASP2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (N-Term) antibodyCASP2 适用: 人, 小鼠 WB, IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users. - 说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- 浓度
- 500 μg/mL
- 缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
- 储存液
- Thimerosal (Merthiolate), Sodium azide
- 注意事项
- This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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: "Effects of PDTC on NF-?B expression and apoptosis in rats with severe acute pancreatitis-associated lung injury." in: International journal of clinical and experimental medicine, Vol. 8, Issue 3, pp. 3258-70, (2015) (PubMed).
: "Apoptosis-related protein expression in rabbits with blast brain injury following early hyperbaric oxygen therapy." in: Neural regeneration research, Vol. 7, Issue 17, pp. 1318-24, (2015) (PubMed).
: "Protective Effects of Baicalin on A?????-Induced Learning and Memory Deficit, Oxidative Stress, and Apoptosis in Rat." in: Cellular and molecular neurobiology, Vol. 35, Issue 5, pp. 623-32, (2015) (PubMed).
: "Inhibitory effect of tetramethylpyrazine preconditioning on overload training-induced myocardial apoptosis in rats." in: Chinese journal of integrative medicine, Vol. 21, Issue 6, pp. 423-30, (2015) (PubMed).
: "Radioprotective activity of neutral polysaccharides isolated from the fruiting bodies of Hohenbuehelia serotina." in: Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), Vol. 31, Issue 4, pp. 352-9, (2015) (PubMed).
: "Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo." in: Molecular medicine reports, Vol. 11, Issue 6, pp. 4142-8, (2015) (PubMed).
: "Aflatoxin B1 affects apoptosis and expression of Bax, Bcl-2, and Caspase-3 in thymus and bursa of fabricius in broiler chickens." in: Environmental toxicology, (2015) (PubMed).
: "Forsythiaside protects against hydrogen peroxide-induced oxidative stress and apoptosis in PC12 cell." in: Neurochemical research, Vol. 40, Issue 1, pp. 27-35, (2015) (PubMed).
: "Colistin-induced apoptosis in PC12 cells: involvement of the mitochondrial apoptotic and death receptor pathways." in: International journal of molecular medicine, Vol. 33, Issue 5, pp. 1298-304, (2014) (PubMed).
: "Apoptotic induction of lung adenocarcinoma A549 cells infected by recombinant RVG Newcastle disease virus (rL-RVG) in vitro." in: Molecular medicine reports, Vol. 11, Issue 1, pp. 317-26, (2014) (PubMed).
: "Protective effects of phillyrin on H2O 2-induced oxidative stress and apoptosis in PC12 cells." in: Cellular and molecular neurobiology, Vol. 34, Issue 8, pp. 1165-73, (2014) (PubMed).
: "8-hydroxy-2-(di-n-propylamino)tetralin intervenes with neural cell apoptosis following diffuse axonal injury." in: Neural regeneration research, Vol. 8, Issue 2, pp. 133-42, (2014) (PubMed).
: "Pathway of programmed cell death and oxidative stress induced by ?-hydroxybutyrate in dairy cow abomasum smooth muscle cells and in mouse gastric smooth muscle." in: PLoS ONE, Vol. 9, Issue 5, pp. e96775, (2014) (PubMed).
: "Toxic effects of sodium fluoride on cell proliferation and apoptosis of Leydig cells from young mice." in: Journal of physiology and biochemistry, Vol. 70, Issue 3, pp. 761-8, (2014) (PubMed).
: "Antitumor effects of artesunate on human breast carcinoma MCF-7 cells and IGF-IR expression in nude mice xenografts." in: Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, Vol. 26, Issue 2, pp. 200-7, (2014) (PubMed).
: "Altholactone induces reactive oxygen species-mediated apoptosis in bladder cancer T24 cells through mitochondrial dysfunction, MAPK-p38 activation and Akt suppression." in: Oncology reports, Vol. 31, Issue 6, pp. 2769-75, (2014) (PubMed).
: "Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction." in: BioMed research international, Vol. 2013, pp. 719858, (2013) (PubMed).
: "Protective role of sodium selenite on histopathological lesions, decreased T-cell subsets and increased apoptosis of thymus in broilers intoxicated with aflatoxin B?." in: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 59, pp. 446-54, (2013) (PubMed).
: "Kinetics of apoptosis and expression of apoptosis-related proteins in rat CA3 hippocampus cells after experimental diffuse brain injury." in: Cell biochemistry and biophysics, Vol. 67, Issue 3, pp. 1015-9, (2013) (PubMed).
: "Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways." in: International journal of oncology, Vol. 40, Issue 4, pp. 1153-61, (2012) (PubMed).
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: "Effects of PDTC on NF-?B expression and apoptosis in rats with severe acute pancreatitis-associated lung injury." in: International journal of clinical and experimental medicine, Vol. 8, Issue 3, pp. 3258-70, (2015) (PubMed).
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- 抗原
- Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))
- 别名
- CASP2 (CASP2 产品)
- 别名
- xCaspase-2 antibody, Caspase-2 antibody, ICH-1 antibody, Nedd2 antibody, CASP-2 antibody, ICH1 antibody, NEDD-2 antibody, NEDD2 antibody, PPP1R57 antibody, ICH-1L/1S antibody, ICH1L1S antibody, caspase 2 antibody, caspase 2 L homeolog antibody, caspase-2 antibody, CASP2 antibody, casp2.L antibody, CpipJ_CPIJ008254 antibody, Casp2 antibody
- 背景
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Caspase-2, which is involved in stress-induced apoptosis, is recruited into a large protein complex, the molecular composition of which remains elusive. activation of caspase-2 occurs in a complex that contains the death domain-containing protein PIDD, whose expression is induced by p53, and the adaptor protein RAIDD. Increased PIDD expression resulted in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli. Caspase-2 acts both as a positive and negative cell death effector, depending upon cell lineage and stage of development.
Synonyms: Apoptosis related cysteine peptidase antibody|CASP 2 antibody|Casp 2L Pro antibody|CASP-2 antibody|CASP2 antibody|CASP2_HUMAN antibody|Caspase 2 apoptosis related cysteine protease antibody|Caspase-2 subunit p12 antibody|Caspase2 antibody|Developmentally down regulated 2 antibody|ICH 1 antibody|ICH 1 protease antibody|ICH 1L antibody|ICH 1L/1S antibody|ICH1 antibody|ICH1 protease antibody|ICH1L antibody|ICH1L/1S antibody|NEDD 2 antibody|NEDD-2 antibody|NEDD2 antibody|NEDD2 apoptosis regulatory gene antibody|Neural precursor cell expressed antibody|Neural precursor cell expressed developmentally down regulated 2 antibody|Neural precursor cell expressed developmentally down-regulated protein 2 antibody|Protease ICH-1 antibody - UniProt
- P42575
- 途径
- Apoptosis, Caspase Cascade in Apoptosis, Neurotrophin Signaling Pathway
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